Academic Journal
An Analysis of Clinical Toxic Effects and Quality of Life as a Function of Radiation Dose and Volume After Lung Stereotactic Body Radiation Therapy
| Title: | An Analysis of Clinical Toxic Effects and Quality of Life as a Function of Radiation Dose and Volume After Lung Stereotactic Body Radiation Therapy |
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| Authors: | Suneetha Devpura, PhD, Aharon M. Feldman, MD, Samuel D. Rusu, MSc, Essa Mayyas, PhD, Avielle Movsas, MD, Stephen L. Brown, PhD, Andrew Cook, MD, Michael J. Simoff, MD, Zhen Sun, MSc, Mei Lu, PhD, Sean Vance, MD, Munther I. Ajlouni, MD, M. Salim Siddiqui, MD, PhD, Indrin J. Chetty, PhD, Benjamin Movsas, MD |
| Source: | Advances in Radiation Oncology, Vol 6, Iss 6, Pp 100815- (2021) |
| Publisher Information: | Elsevier, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Purpose: To analyze clinical toxicity and quality-of-life (QOL) outcomes among patients with stage I non-small cell lung cancer (NSCLC) after stereotactic body radiation therapy (SBRT) as a function of radiation dose and volume parameters. Methods and Materials: In this institutional review board–approved study, 55 patients with stage I NSCLC who received SBRT (12 Gy × 4) and completed QOL forms were analyzed. Clinical symptoms and QOL outcomes were measured at baseline and at 3, 6, 12, 18, 24, and 36 months after SBRT. Clinical toxicity was graded using the Common Terminology Criteria for Adverse Events, version 4.0. Quality of life was followed using the validated Functional Assessment of Cancer Therapy-Lung-Trial Outcome Index (FACT-L-TOI) instrument. Dosimetric parameters including the mean lung radiation dose and the volume of normal lung receiving greater than 5, 10, 13, or 20 Gy (V5, V10, V13, and V20) were measured from the radiation treatment plan. Student t tests and Pearson correlation analyses were used to examine the relationships between radiation lung metrics and clinically meaningful changes in QOL and/or clinical toxic effects. The Kaplan-Meier method was used to estimate rates of local control (LC), disease-free survival (DFS), and overall survival (OS). Results: With a median follow-up of 24 months, the 3-year LC, DFS, and OS were 93%, 65%, and 84%, respectively, with a 5.5% rate of grade-3 toxic effects and no grade 4 or 5 toxic effects. Clinically meaningful declines in patient-reported QOL (FACT-L-TOI, lung cancer subscale, physical well-being, and/or functional well-being) posttreatment significantly correlated with increased dosimetric parameters such as V10, V13, and V20. Conclusion: Although lung SBRT was associated with excellent LC and minimal clinical toxic effects for early-stage NSCLC, clinically meaningful declines in QOL were significantly correlated with increasing lung dose and volume parameters. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2452-1094 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452109421001731; https://doaj.org/toc/2452-1094 |
| DOI: | 10.1016/j.adro.2021.100815 |
| Access URL: | https://doaj.org/article/2b1f4c95832c4470898e15d321d774e0 |
| Accession Number: | edsdoj.2b1f4c95832c4470898e15d321d774e0 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24521094 |
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| DOI: | 10.1016/j.adro.2021.100815 |
| Published in: | Advances in Radiation Oncology |
| Language: | English |