Exploring a Novel Approach to Spare Classic Chemotherapy in HER2-Low, ER-Positive Breast Cancer Based on Trastuzumab Deruxtecan Combined with Endocrine Therapy
| Title: | Exploring a Novel Approach to Spare Classic Chemotherapy in HER2-Low, ER-Positive Breast Cancer Based on Trastuzumab Deruxtecan Combined with Endocrine Therapy |
|---|---|
| Authors: | Luca Scafuri, Carlo Buonerba, Vincenzo Di Lauro, Vincenzo Tortora, Marco Cascella, Luigi Liguori, Antonella Sciarra, Francesco Sabbatino, Anna Diana, Antonio Marra, Paolo Tarantino, Dario Trapani, Mario Giuliano, Grazia Arpino, Giuseppe Curigliano, Giuseppe Di Lorenzo |
| Source: | Oncology and Therapy, Vol 12, Iss 3, Pp 363-373 (2024) |
| Publisher Information: | Adis, Springer Healthcare, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Breast cancer, HER2-low, Estrogen receptor-positive, Neoadjuvant therapy, Trastuzumab deruxtecan, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Abstract Background Breast cancer presents diverse molecular subtypes affecting treatment strategies. Human epidermal growth factor receptor 2 (HER2)-low, hormone receptor-positive (HR+) breast cancer poses a challenge due to limited targeted therapies. Current neoadjuvant treatment primarily utilizes chemotherapy, with conflicting results regarding efficacy in patients with HER2-low breast cancer. Trastuzumab deruxtecan (T-DXd) shows promise in HER2-low metastatic disease, and preliminary evidence suggests synergy with endocrine therapy. Objective This editorial explores the hypothesis that neoadjuvant T-DXd with or without endocrine therapy offers efficacy in the clinical management of HR+/HER2-low breast cancer. Methods We propose a phase II study with two treatment arms: T-DXd + letrozole and T-DXd alone. The primary endpoint is the radiological complete response rate. Secondary endpoints include pathological complete response rate, safety, event-free survival, and overall survival. Exploratory analyses will compare the arms to identify potential for optimizing treatment efficacy and minimizing side effects. Conclusions This study design allows for initial assessment of T-DXd with or without endocrine therapy in the treatment of HER2-low breast cancer. The findings may pave the way for personalized treatment strategies and inform future research, potentially leading to a chemotherapy-sparing approach. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2366-1070 2366-1089 |
| Relation: | https://doaj.org/toc/2366-1070; https://doaj.org/toc/2366-1089 |
| DOI: | 10.1007/s40487-024-00286-3 |
| Access URL: | https://doaj.org/article/2b162889839543f080aaba98a06a8db9 |
| Accession Number: | edsdoj.2b162889839543f080aaba98a06a8db9 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23661070 23661089 |
|---|---|
| DOI: | 10.1007/s40487-024-00286-3 |
| Published in: | Oncology and Therapy |
| Language: | English |