Bibliographic Details
| Title: |
Immediate cardiopulmonary responses to consecutive pulmonary embolism: a randomized, controlled, experimental study |
| Authors: |
Mads Dam Lyhne, Jacob Gammelgaard Schultz, Christian Schmidt Mortensen, Anders Kramer, Jens Erik Nielsen-Kudsk, Asger Andersen |
| Source: |
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-9 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the respiratory system |
| Subject Terms: |
Right ventricular function, Pulmonary circulation, Right ventricular afterload, Ventilation-perfusion mismatch, Gas exchange, Animal model, Diseases of the respiratory system, RC705-779 |
| More Details: |
Abstract Background Acute pulmonary embolism (PE) induces ventilation-perfusion mismatch and hypoxia and increases pulmonary pressure and right ventricular (RV) afterload, entailing potentially fatal RV failure within a short timeframe. Cardiopulmonary factors may respond differently to increased clot burden. We aimed to elucidate immediate cardiopulmonary responses during successive PE episodes in a porcine model. Methods This was a randomized, controlled, blinded study of repeated measurements. Twelve pigs were randomly assigned to receive sham procedures or consecutive PEs every 15 min until doubling of mean pulmonary pressure. Cardiopulmonary assessments were conducted at 1, 2, 5, and 13 min after each PE using pressure-volume loops, invasive pressures, and arterial and mixed venous blood gas analyses. ANOVA and mixed-model statistical analyses were applied. Results Pulmonary pressures increased after the initial PE administration (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2466 |
| Relation: |
https://doaj.org/toc/1471-2466 |
| DOI: |
10.1186/s12890-024-03006-9 |
| Access URL: |
https://doaj.org/article/2aff277517ee4fabab944f76a2c178a9 |
| Accession Number: |
edsdoj.2aff277517ee4fabab944f76a2c178a9 |
| Database: |
Directory of Open Access Journals |
