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The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders

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Title: The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders
Authors: Simona Dedoni, Chiara Camoglio, Carlotta Siddi, Maria Scherma, Walter Fratta, Paola Fadda
Source: Future Pharmacology, Vol 4, Iss 1, Pp 199-221 (2024)
Publisher Information: MDPI AG, 2024.
Publication Year: 2024
Collection: LCC:Therapeutics. Pharmacology
Subject Terms: lysophosphatidic acid (LPA), neuropsychiatric disorders, neurodegenerative disorders, major depressive disorder (MDD), schizophrenia (SCZ), Alzheimer’s disease (AD), Therapeutics. Pharmacology, RM1-950
More Details: Individuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes. Lysophosphatidic acid (LPA) is a bioactive phospholipid and a crucial regulator of the development of adult neuronal systems; hence, it may play an important role in the onset of certain diseases such as Alzheimer’s, Parkinson’s disease, and schizophrenia. During development, LPA signaling regulates many cellular processes such as proliferation, survival, migration, differentiation, cytoskeleton reorganization, and DNA synthesis. So far, six lysophosphatidic acid receptors that respond to LPA have been discovered and categorized based on their homology. Despite the abundance of evidence relating LPA cellular activities to different pathological conditions, little is known about the involvement of LPA in the field of neuropsychiatric and neurodegenerative diseases. The purpose of this review is to define LPA activities related to the illnesses stated above in order to better understand these pathologies and provide future novel treatment strategies based on the latest data.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2673-9879
Relation: https://www.mdpi.com/2673-9879/4/1/14; https://doaj.org/toc/2673-9879
DOI: 10.3390/futurepharmacol4010014
Access URL: https://doaj.org/article/2a96d6f3a8854bc9aaec27898a05ed26
Accession Number: edsdoj.2a96d6f3a8854bc9aaec27898a05ed26
Database: Directory of Open Access Journals
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  Data: The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders
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  Data: <searchLink fieldCode="AR" term="%22Simona+Dedoni%22">Simona Dedoni</searchLink><br /><searchLink fieldCode="AR" term="%22Chiara+Camoglio%22">Chiara Camoglio</searchLink><br /><searchLink fieldCode="AR" term="%22Carlotta+Siddi%22">Carlotta Siddi</searchLink><br /><searchLink fieldCode="AR" term="%22Maria+Scherma%22">Maria Scherma</searchLink><br /><searchLink fieldCode="AR" term="%22Walter+Fratta%22">Walter Fratta</searchLink><br /><searchLink fieldCode="AR" term="%22Paola+Fadda%22">Paola Fadda</searchLink>
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  Data: Future Pharmacology, Vol 4, Iss 1, Pp 199-221 (2024)
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  Data: MDPI AG, 2024.
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  Data: LCC:Therapeutics. Pharmacology
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  Data: <searchLink fieldCode="DE" term="%22lysophosphatidic+acid+%28LPA%29%22">lysophosphatidic acid (LPA)</searchLink><br /><searchLink fieldCode="DE" term="%22neuropsychiatric+disorders%22">neuropsychiatric disorders</searchLink><br /><searchLink fieldCode="DE" term="%22neurodegenerative+disorders%22">neurodegenerative disorders</searchLink><br /><searchLink fieldCode="DE" term="%22major+depressive+disorder+%28MDD%29%22">major depressive disorder (MDD)</searchLink><br /><searchLink fieldCode="DE" term="%22schizophrenia+%28SCZ%29%22">schizophrenia (SCZ)</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer%27s+disease+%28AD%29%22">Alzheimer’s disease (AD)</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%2E+Pharmacology%22">Therapeutics. Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22RM1-950%22">RM1-950</searchLink>
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  Data: Individuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes. Lysophosphatidic acid (LPA) is a bioactive phospholipid and a crucial regulator of the development of adult neuronal systems; hence, it may play an important role in the onset of certain diseases such as Alzheimer’s, Parkinson’s disease, and schizophrenia. During development, LPA signaling regulates many cellular processes such as proliferation, survival, migration, differentiation, cytoskeleton reorganization, and DNA synthesis. So far, six lysophosphatidic acid receptors that respond to LPA have been discovered and categorized based on their homology. Despite the abundance of evidence relating LPA cellular activities to different pathological conditions, little is known about the involvement of LPA in the field of neuropsychiatric and neurodegenerative diseases. The purpose of this review is to define LPA activities related to the illnesses stated above in order to better understand these pathologies and provide future novel treatment strategies based on the latest data.
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      – SubjectFull: lysophosphatidic acid (LPA)
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