Bibliographic Details
| Title: |
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis |
| Authors: |
Luca Muzio, Riccardo Sirtori, Davide Gornati, Simona Eleuteri, Andrea Fossaghi, Diego Brancaccio, Leonardo Manzoni, Linda Ottoboni, Luca De Feo, Angelo Quattrini, Eloise Mastrangelo, Luca Sorrentino, Emanuele Scalone, Giancarlo Comi, Luciana Marinelli, Nilo Riva, Mario Milani, Pierfausto Seneci, Gianvito Martino |
| Source: |
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
| Publisher Information: |
Nature Portfolio, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer stability ameliorating the disease phenotype. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-17524-7 |
| Access URL: |
https://doaj.org/article/2a79c2c4685b4d2598d773092d995d7b |
| Accession Number: |
edsdoj.2a79c2c4685b4d2598d773092d995d7b |
| Database: |
Directory of Open Access Journals |
