Bibliographic Details
| Title: |
Microvascular Disease Associates with Larger Osteocyte Lacunae in Cortical Bone in Type 2 Diabetes Mellitus |
| Authors: |
Sebastian Zanner, Elliott Goff, Samuel Ghatan, Eva Maria Wölfel, Charlotte Ejersted, Gisela Kuhn, Ralph Müller, Morten Frost |
| Source: |
JBMR Plus, Vol 7, Iss 11, Pp n/a-n/a (2023) |
| Publisher Information: |
Oxford University Press, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Orthopedic surgery
LCC:Diseases of the musculoskeletal system |
| Subject Terms: |
ANALYSIS/QUANTITATION OF BONE, BIOMECHANICS, BONE QCT/MICRO‐CT, CELLS OF BONE, OSTEOCYTES, ORTHOPEDICS, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935 |
| More Details: |
ABSTRACT Clinical studies indicate that microvascular disease (MVD) affects bone microstructure and decreases bone strength in type 2 diabetes mellitus (T2D). Osteocytes are housed in small voids within the bone matrix and lacunae and act as sensors of mechanical forces in bone. These cells regulate osteoclastic bone resorption and osteoblastic bone formation as well as osteocytic perilacunar remodeling. We hypothesized that MVD changes morphometric osteocyte lacunar parameters in individuals with T2D. We collected iliac crest bone biopsies from 35 individuals (10 female, 25 male) with T2D with MVD (15%) or without MVD (21%) with a median age of 67 years (interquartile range [IQR] 62–72 years). The participants were included based on c‐peptide levels >700 pmol L−1, absence of anti‐GAD65 antibodies, and glycated hemoglobin (HbA1c) levels between 40 and 82 mmol mol−1 or 5.8% and 9.7%, respectively. We assessed osteocyte lacunar morphometric parameters in trabecular and cortical bone regions using micro‐computed tomography (micro‐CT) at a nominal resolution of 1.2 μm voxel size. The cortical osteocyte lacunar volume (Lc.V) was 7.7% larger (p = 0.05) and more spherical (Lc.Sr, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2473-4039 |
| Relation: |
https://doaj.org/toc/2473-4039 |
| DOI: |
10.1002/jbm4.10832 |
| Access URL: |
https://doaj.org/article/ae2a4857ac274e308fa19cb33a56fc32 |
| Accession Number: |
edsdoj.2a4857ac274e308fa19cb33a56fc32 |
| Database: |
Directory of Open Access Journals |
