Bibliographic Details
| Title: |
Generation and characterization of induced pluripotent stem cells heterozygous for the Portuguese BRCA2 founder mutation |
| Authors: |
Teresa P. Silva, Carolina A. Pereira, Ana Cláudia Raposo, Ana Rita Oliveira, Maria Arez, Joaquim M.S. Cabral, Inês Milagre, Maria Carmo-Fonseca, Simão Teixeira da Rocha |
| Source: |
Stem Cell Research, Vol 53, Iss , Pp 102364- (2021) |
| Publisher Information: |
Elsevier, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
Biology (General), QH301-705.5 |
| More Details: |
Women who inherit heterozygous mutations in the BRCA2 gene have an increased risk of developing cancer, mainly breast and ovarian tumors. A particular BRCA2 mutation (c.156_157insAlu) is exclusively found in families of Portuguese ancestry and is present in approximately 30% of all Portuguese families with hereditary breast and ovarian cancers. We report the generation and characterization of the first iPSC line from a female donor harboring the Portuguese BRCA2 founder mutation. Skin fibroblasts were reprogrammed using a non-integrative Sendai virus. These iPSCs are a valuable tool to study the origin of BRCA2-associated cancer in its earliest phases. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1873-5061 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1873506121002105; https://doaj.org/toc/1873-5061 |
| DOI: |
10.1016/j.scr.2021.102364 |
| Access URL: |
https://doaj.org/article/2a040b6245af402fbc8435ef6d6ffeb2 |
| Accession Number: |
edsdoj.2a040b6245af402fbc8435ef6d6ffeb2 |
| Database: |
Directory of Open Access Journals |
