Academic Journal
A Five-miRNA Panel Identified From a Multicentric Case–control Study Serves as a Novel Diagnostic Tool for Ethnically Diverse Non-small-cell Lung Cancer Patients
| Title: | A Five-miRNA Panel Identified From a Multicentric Case–control Study Serves as a Novel Diagnostic Tool for Ethnically Diverse Non-small-cell Lung Cancer Patients |
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| Authors: | Cheng Wang, Meng Ding, Mingde Xia, Sidi Chen, Anh Van Le, Rafael Soto-Gil, Yi Shen, Nan Wang, Junjun Wang, Wanjian Gu, Xiangdong Wang, Yanni Zhang, Ke Zen, Xi Chen, Chunni Zhang, Chen-Yu Zhang |
| Source: | EBioMedicine, Vol 2, Iss 10, Pp 1377-1385 (2015) |
| Publisher Information: | Elsevier, 2015. |
| Publication Year: | 2015 |
| Collection: | LCC:Medicine LCC:Medicine (General) |
| Subject Terms: | Non-small-cell lung cancer, Multiethnic, Multicentric, Serum microRNAs, Biomarker, Diagnosis, Medicine, Medicine (General), R5-920 |
| More Details: | Circulating microRNAs (miRNAs) are promising biomarkers for cancer detection. However, multiethnic and multicentric studies of non-small-cell lung cancer (NSCLC) are lacking. We recruited 221 NSCLC patients, 161 controls and 56 benign nodules from both China and America. Initial miRNA screening was performed using the TaqMan Low Density Array followed by confirming individually by RT-qPCR in Chinese cohorts. Finally, we performed a blind trial from an American cohort to validate our findings. RT-qPCR confirmed that miR-483-5p, miR-193a-3p, miR-25, miR-214 and miR-7 were significantly elevated in patients compared to controls. The areas under the curve (AUCs) of the ROC curve of this five-serum miRNA panel were 0.976 (95% CI, 0.939–1.0; P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3964 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352396415300864; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2015.07.034 |
| Access URL: | https://doaj.org/article/a2a01404ad6a4356b4ec51ab954db871 |
| Accession Number: | edsdoj.2a01404ad6a4356b4ec51ab954db871 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2015.07.034 |
| Published in: | EBioMedicine |
| Language: | English |