Bibliographic Details
| Title: |
Personalization in Modern Radiation Oncology: Methods, Results and Pitfalls. Personalized Interventions and Breast Cancer |
| Authors: |
Cynthia Aristei, Elisabetta Perrucci, Emanuele Alì, Fabio Marazzi, Valeria Masiello, Simonetta Saldi, Gianluca Ingrosso |
| Source: |
Frontiers in Oncology, Vol 11 (2021) |
| Publisher Information: |
Frontiers Media S.A., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
breast cancer, personalized medicine, precision medicine, radiation oncology, biomarkers, molecular subtypes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Breast cancer, the most frequent malignancy in women worldwide, is a heterogeneous group of diseases, characterized by distinct molecular aberrations. In precision medicine, radiation oncology for breast cancer aims at tailoring treatment according to tumor biology and each patient’s clinical features and genetics. Although systemic therapies are personalized according to molecular sub-type [i.e. endocrine therapy for receptor-positive disease and anti-human epidermal growth factor receptor 2 (HER2) therapy for HER2-positive disease] and multi-gene assays, personalized radiation therapy has yet to be adopted in the clinical setting. Currently, attempts are being made to identify prognostic and/or predictive factors, biomarkers, signatures that could lead to personalized treatment in order to select appropriate patients who might, or might not, benefit from radiation therapy or whose radiation therapy might be escalated or de-escalated in dosages and volumes. This overview focuses on what has been achieved to date in personalized post-operative radiation therapy and individual patient radiosensitivity assessments by means of tumor sub-types and genetics. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2021.616042/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2021.616042 |
| Access URL: |
https://doaj.org/article/e29df89de92d47e8bce2244e12b38550 |
| Accession Number: |
edsdoj.29df89de92d47e8bce2244e12b38550 |
| Database: |
Directory of Open Access Journals |
