Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome
| Title: | Neutralizing Antibodies and Sin Nombre Virus RNA after Recovery from Hantavirus Cardiopulmonary Syndrome |
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| Authors: | Chunyan Ye, Joseph B. Prescott, Robert A. Nofchissey, Diane Goade, Brian Hjelle |
| Source: | Emerging Infectious Diseases, Vol 10, Iss 3, Pp 478-482 (2004) |
| Publisher Information: | Centers for Disease Control and Prevention, 2004. |
| Publication Year: | 2004 |
| Collection: | LCC:Medicine LCC:Infectious and parasitic diseases |
| Subject Terms: | hantavirus, Sin Nombre virus, hantavirus cardiopulmonary syndrome, persistence, HCPS, neutralizing antibody, Medicine, Infectious and parasitic diseases, RC109-216 |
| More Details: | Patients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have recovered from HCPS to those in the early stages of disease may be an advantageous form of passive immunotherapy, we examined the neutralizing antibody titers of 21 patients who had recovered from SNV infection. Even 1,000 days after admission to the hospital, 6 of 10 patients had titers of 800 or higher, with one sample retaining a titer of 3,200 after more than 1,400 days. None of the convalescent-phase serum samples contained detectable viral RNA. These results confirm that patients retain high titers of neutralizing antibodies long after recovery from SNV infection. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/10/3/02-0821_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid1003.020821 |
| Access URL: | https://doaj.org/article/29cb9e790ef64c6e963260acf8cfca76 |
| Accession Number: | edsdoj.29cb9e790ef64c6e963260acf8cfca76 |
| Database: | Directory of Open Access Journals |
| ISSN: | 10806040 10806059 |
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| DOI: | 10.3201/eid1003.020821 |
| Published in: | Emerging Infectious Diseases |
| Language: | English |