Bibliographic Details
| Title: |
Stem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours |
| Authors: |
Kristin Astrid Øystese, Nicoleta Cristina Olarescu, Cecilia Lindskog, Fabjola Xheka, Jon Berg-Johnsen, Jens Petter Berg, Jens Bollerslev, Olivera Casar-Borota |
| Source: |
Free Neuropathology, Vol 5 (2024) |
| Publisher Information: |
University of Münster / Open Journals System, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
Pituitary neoplasm, Non-functioning pituitary adenoma, Neoplastic stem cells, Stem cells, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Background: Cells with stem cell features have been described in pituitary neuroendocrine tumours (PitNETs). Transcription factors SOX2 and SOX9 are stem cell-associated markers while the pituitary progenitor marker PROP1 is involved in anterior pituitary development. We characterised the presence of these markers known to be present in the human pituitary in non-functioning (NF) PitNETs. Methods: We investigated the pituitary transcription factors SOX2, SOX9 and PROP1 by immunohistochemistry (IHC) (N = 125) and RT-qPCR (N = 78) in a retrospective cohort of clinically NF-PitNETs. The markers were scored based on the percentage of immunolabeled cells. IHC staining scores were compared to reintervention rates for the whole cohort, and to expression of FSH, LH or ER in gonadotroph NF-PitNETs. Results: Most tumours showed no or few cells positive for SOX2, SOX9 and PROP1. More patients with SOX2-negative tumours went through reintervention (40 % vs 19 %, p = 0.03). SOX2, SOX9 and PROP1 staining correlated positively to each other (SOX2 and SOX9 rs = 0.666, SOX2 and PROP1 rs = 0.704, SOX9 and PROP1 rs = 0.570, and p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2699-4445 |
| Relation: |
https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/5396; https://doaj.org/toc/2699-4445 |
| DOI: |
10.17879/freeneuropathology-2024-5396 |
| Access URL: |
https://doaj.org/article/aac2997618ff4395a7a24b6a31018e71 |
| Accession Number: |
edsdoj.2997618ff4395a7a24b6a31018e71 |
| Database: |
Directory of Open Access Journals |
