Lipopolysaccharide-binding protein and future Parkinson’s disease risk: a European prospective cohort

Bibliographic Details
Title: Lipopolysaccharide-binding protein and future Parkinson’s disease risk: a European prospective cohort
Authors: Yujia Zhao, Douglas I. Walker, Christina M. Lill, Bastiaan R. Bloem, Sirwan K. L. Darweesh, Brismar Pinto-Pacheco, Brooklyn McNeil, Gary W. Miller, Alicia K. Heath, Myrthe Frissen, Dafina Petrova, Maria-Jose Sánchez, María-Dolores Chirlaque, Marcela Guevara, Maurizio Zibetti, Salvatore Panico, Lefkos Middleton, Verena Katzke, Rudolf Kaaks, Elio Riboli, Giovanna Masala, Sabina Sieri, Raul Zamora-Ros, Pilar Amiano, Mazda Jenab, Susan Peters, Roel Vermeulen
Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-8 (2023)
Publisher Information: BMC, 2023.
Publication Year: 2023
Collection: LCC:Neurology. Diseases of the nervous system
Subject Terms: Parkinson’s disease, Lipopolysaccharide-binding protein, Pre-diagnostic, Systemic inflammation, Endotoxemia, Neurology. Diseases of the nervous system, RC346-429
More Details: Abstract Introduction Lipopolysaccharide (LPS) is the outer membrane component of Gram-negative bacteria. LPS-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by LPS and has been used as a blood marker for LPS. LBP has recently been indicated to be associated with Parkinson’s disease (PD) in small-scale retrospective case–control studies. We aimed to investigate the association between LBP blood levels with PD risk in a nested case–control study within a large European prospective cohort. Methods A total of 352 incident PD cases (55% males) were identified and one control per case was selected, matched by age at recruitment, sex and study center. LBP levels in plasma collected at recruitment, which was on average 7.8 years before diagnosis of the cases, were analyzed by enzyme linked immunosorbent assay. Odds ratios (ORs) were estimated for one unit increase of the natural log of LBP levels and PD incidence by conditional logistic regression. Results Plasma LBP levels were higher in prospective PD cases compared to controls (median (interquartile range) 26.9 (18.1–41.0) vs. 24.7 (16.6–38.4) µg/ml). The OR for PD incidence per one unit increase of log LBP was elevated (1.46, 95% CI 0.98–2.19). This association was more pronounced among women (OR 2.68, 95% CI 1.40–5.13) and overweight/obese subjects (OR 1.54, 95% CI 1.09–2.18). Conclusion The findings suggest that higher plasma LBP levels may be associated with an increased risk of PD and may thus pinpoint to a potential role of endotoxemia in the pathogenesis of PD, particularly in women and overweight/obese individuals.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1742-2094
Relation: https://doaj.org/toc/1742-2094
DOI: 10.1186/s12974-023-02846-2
Access URL: https://doaj.org/article/2962f05fe2fc4dd3bda9fce1be26ad3b
Accession Number: edsdoj.2962f05fe2fc4dd3bda9fce1be26ad3b
Database: Directory of Open Access Journals
Full text is not displayed to guests.
More Details
ISSN:17422094
DOI:10.1186/s12974-023-02846-2
Published in:Journal of Neuroinflammation
Language:English