Staphylococcus aureus Pneumonia in Can Tho, Vietnam: Clinical Characteristics, Antimicrobial Resistance Profile and Risk Factors of Mortality
| Title: | Staphylococcus aureus Pneumonia in Can Tho, Vietnam: Clinical Characteristics, Antimicrobial Resistance Profile and Risk Factors of Mortality |
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| Authors: | Thu Vo-Pham-Minh, Dang Tran-Cong, Hung Phan-Viet, Thien Dinh-Chi, Tran Nguyen-Thi-Hong, Thuy Cao-Thi-My, Hien Nguyen-Thi-Dieu, Duong Vo-Thai, Vu Nguyen-Thien, Sy Duong-Quy |
| Source: | Pulmonary Therapy, Vol 10, Iss 2, Pp 193-205 (2024) |
| Publisher Information: | Adis, Springer Healthcare, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the respiratory system |
| Subject Terms: | Staphylococcus aureus, Pneumonia, Antimicrobial resistance, Risk factors, Diseases of the respiratory system, RC705-779 |
| More Details: | Abstract Introduction Staphylococcus aureus (S. aureus) is an important pathogen in both community-acquired and hospital-acquired pneumonia. S. aureus pneumonia has a high mortality rate and serious complications. Resistance to multiple antibiotics is a major challenge in the treatment of S. aureus pneumonia. Understanding the antibiotic resistance profile of S. aureus and the risk factors for mortality can help optimize antibiotic regimens and improve patient outcomes in S. aureus pneumonia. Methods A prospective cohort study of 118 patients diagnosed with S. aureus pneumonia between May 2021 and June 2023 was conducted, with a 30-day follow-up period. Demographic information, comorbidities, Charlson Comorbidity Index, clinical characteristics, outcomes, and complications were collected for each enrolled case. The data were processed and analyzed using R version 3.6.2. Results S. aureus pneumonia has a 30-day mortality rate of approximately 50%, with complication rates of 22% for acute respiratory distress syndrome (ARDS), 26.3% for septic shock, and 14.4% for acute kidney injury (AKI). Among patients with methicillin-resistant S. aureus (MRSA) pneumonia treated with vancomycin (n = 40), those with a vancomycin minimum inhibitory concentration (MIC) ≤ 1 had significantly higher cumulative survival at day 30 compared to those with MIC ≥ 2 (log-rank test p = 0.04). The prevalence of MRSA among S. aureus isolates was 84.7%. Hemoptysis, methicillin resistance, acidosis (pH |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2364-1754 2364-1746 |
| Relation: | https://doaj.org/toc/2364-1754; https://doaj.org/toc/2364-1746 |
| DOI: | 10.1007/s41030-024-00254-2 |
| Access URL: | https://doaj.org/article/e2959f9aeb5248fc90d9f4854df8bbf0 |
| Accession Number: | edsdoj.2959f9aeb5248fc90d9f4854df8bbf0 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23641754 23641746 |
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| DOI: | 10.1007/s41030-024-00254-2 |
| Published in: | Pulmonary Therapy |
| Language: | English |