Bibliographic Details
| Title: |
Review The Emerging Profile of Cross-Resistance among the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors |
| Authors: |
Nicolas Sluis-Cremer |
| Source: |
Viruses, Vol 6, Iss 8, Pp 2960-2973 (2014) |
| Publisher Information: |
MDPI AG, 2014. |
| Publication Year: |
2014 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
HIV, reverse transcriptase, nonnucleoside inhibitors, nevirapine, efavirenz, rilpivirine, etravirine, dapivirine, MIV-150, Microbiology, QR1-502 |
| More Details: |
Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are widely used to treat HIV-1-infected individuals; indeed most first-line antiretroviral therapies typically include one NNRTI in combination with two nucleoside analogs. In 2008, the next-generation NNRTI etravirine was approved for the treatment of HIV-infected antiretroviral therapy-experienced individuals, including those with prior NNRTI exposure. NNRTIs are also increasingly being included in strategies to prevent HIV-1 infection. For example: (1) nevirapine is used to prevent mother-to-child transmission; (2) the ASPIRE (MTN 020) study will test whether a vaginal ring containing dapivirine can prevent HIV-1 infection in women; (3) a microbicide gel formulation containing the urea-PETT derivative MIV-150 is in a phase I study to evaluate safety, pharmacokinetics, pharmacodynamics and acceptability; and (4) a long acting rilpivirine formulation is under-development for pre-exposure prophylaxis. Given their widespread use, particularly in resource-limited settings, as well as their low genetic barriers to resistance, there are concerns about overlapping resistance between the different NNRTIs. Consequently, a better understanding of the resistance and cross-resistance profiles among the NNRTI class is important for predicting response to treatment, and surveillance of transmitted drug-resistance. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4915 |
| Relation: |
http://www.mdpi.com/1999-4915/6/8/2960; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v6082960 |
| Access URL: |
https://doaj.org/article/294a66db67b5403b8ab48bc7a1ea5686 |
| Accession Number: |
edsdoj.294a66db67b5403b8ab48bc7a1ea5686 |
| Database: |
Directory of Open Access Journals |
