| Title: |
Combining Surgery, Radiotherapy, and Topical Chemotherapy to Prevent Primary Orbital Exenteration for Atypical Caruncular Melanoma: A Case Report |
| Authors: |
Cédric De Landsheer, Valentien Merlevede, Celine Jacobs, Jo Van Dorpe, Julie De Zaeytijd, Virginie G.S. Ninclaus, Dimitri Roels |
| Source: |
Case Reports in Ophthalmology, Vol 15, Iss 1, Pp 212-219 (2024) |
| Publisher Information: |
Karger Publishers, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Ophthalmology |
| Subject Terms: |
caruncular melanoma, topical chemotherapy, 5-fluorouracil, external beam radiotherapy, case report, Ophthalmology, RE1-994 |
| More Details: |
Introduction: This case report demonstrates the possibility of successful eye and vision-sparing therapy for caruncular melanoma. Case Presentation: We present an atypical presentation of a caruncular melanoma. After excisional biopsy, residual flat conjunctival melanosis resolved using topical chemotherapy (5-fluorouracil), which was well tolerated. Relapse of the melanoma was treated with external beam radiotherapy, but the tumor grew despite treatment. Eighteen months after complete excision of the relapsed melanoma, the patient remains tumor-free while the eye and its function remain preserved. Conclusion: This case report suggests that aggressive eye-sparing therapy for caruncular melanoma combining surgery, adjuvant topical chemotherapy, and external beam radiotherapy, can be an alternative for primary orbital exenteration. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1663-2699 |
| Relation: |
https://beta.karger.com/Article/FullText/536590; https://doaj.org/toc/1663-2699 |
| DOI: |
10.1159/000536590 |
| Access URL: |
https://doaj.org/article/28ad9b59d1fc4a5a8b1b8bcb60802d16 |
| Accession Number: |
edsdoj.28ad9b59d1fc4a5a8b1b8bcb60802d16 |
| Database: |
Directory of Open Access Journals |
