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White matter integrity in mice requires continuous myelin synthesis at the inner tongue

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Title: White matter integrity in mice requires continuous myelin synthesis at the inner tongue
Authors: Martin Meschkat, Anna M. Steyer, Marie-Theres Weil, Kathrin Kusch, Olaf Jahn, Lars Piepkorn, Paola Agüi-Gonzalez, Nhu Thi Ngoc Phan, Torben Ruhwedel, Boguslawa Sadowski, Silvio O. Rizzoli, Hauke B. Werner, Hannelore Ehrenreich, Klaus-Armin Nave, Wiebke Möbius
Source: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Publisher Information: Nature Portfolio, 2022.
Publication Year: 2022
Collection: LCC:Science
Subject Terms: Science
More Details: Myelin is formed of proteins of long half-lives. The mechanisms of renewal of such a stable structure are unclear. Here, the authors show that myelin integrity requires continuous myelin synthesis at the inner tongue, contributing to the maintenance of a functional axon-myelin unit.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-022-28720-y
Access URL: https://doaj.org/article/287e7feee643483fbef3a7725df08a2f
Accession Number: edsdoj.287e7feee643483fbef3a7725df08a2f
Database: Directory of Open Access Journals
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