Bibliographic Details
| Title: |
Safety of measles, mumps, and rubella vaccine in egg allergy: in vivo and in vitro management |
| Authors: |
Stefania Magistà , Marcello Albanesi, Nada Chaoul, Danilo Di Bona, Elisabetta Di Leo, Eustachio Nettis, Maria Filomena Caiaffa, Luigi Macchia |
| Source: |
Clinical and Molecular Allergy, Vol 18, Iss 1, Pp 1-5 (2020) |
| Publisher Information: |
BMC, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
Vaccine adverse reaction, Food allergy, Drug allergy, Anaphylaxis, B-cell proliferation assay, Flow cytometry, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Abstract Background Egg allergy is the second most prevalent form of food allergy in childhood. In spite of the evidence accumulated, inoculating egg allergy children with attenuated vaccines grown on chick embryo cell cultures, such as the measles, mumps, and rubella (MMR) vaccine, is regarded (erroneously) as potentially dangerous or even anaphylactogenic, by many. An issue perceived as particularly conflicting also by Health Professionals. Case presentation A 15-year-old boy, with a history of severe egg allergy in early infancy, who was still sensitized to egg allergens, including baked egg, had never received MMR vaccination, in fear of possible anaphylaxis, in spite of the fact that this vaccination is mandatory in the first year of life, in Italy. Because of that, he was not allowed to attend school, longer, and was referred to us in order to assess the potential risk of MMR vaccination. Upon thorough allergologic workup, sensitization to MMR vaccine components was excluded by an in vivo approach, consisting in skin prick tests, intradermal tests, and subcutaneous injection test, corroborated by vaccine-specific B-lymphocyte proliferation assay, ex vivo. T-cell proliferation in response to MMR vaccine was also excluded. Eventually, the boy was inoculated with MMR vaccine and was readmitted to school. Conclusions The diagnostic strategy adopted appears feasible and easy-to-perform and may be adopted in controversial cases (as the one reported), characterized by previous severe allergic reactions to egg. The B-lymphocyte proliferation assay we developed may represent a useful and reliable tool not only in research but also in clinical practice. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1476-7961 |
| Relation: |
http://link.springer.com/article/10.1186/s12948-020-00136-3; https://doaj.org/toc/1476-7961 |
| DOI: |
10.1186/s12948-020-00136-3 |
| Access URL: |
https://doaj.org/article/a285dba5564147b795614908998ff4c8 |
| Accession Number: |
edsdoj.285dba5564147b795614908998ff4c8 |
| Database: |
Directory of Open Access Journals |
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