Comparative membrane proteomic analysis of Tritrichomonas foetus isolates

Bibliographic Details
Title:	Comparative membrane proteomic analysis of Tritrichomonas foetus isolates
Authors:	Maria B. Rivero, Andrés M. Alonso, Maria E. Abdala, Melchor E. Luque, Pedro G. Carranza, Veronica M. Coceres, Fernando D. Rivero
Source:	Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Publisher Information:	Nature Portfolio, 2024.
Publication Year:	2024
Collection:	LCC:Medicine LCC:Science
Subject Terms:	Tritrichomonas foetus isolates, Membrane proteins, Diagnosis, Medicine, Science
More Details:	Abstract Tritrichomonas foetus is a flagellated and anaerobic parasite able to infect cattle and felines. Despite its prevalence, there is no effective standardized or legal treatment for T. foetus-infected cattle; the vaccination still has limited success in mitigating infections and reducing abortion risk; and nowadays, the diagnosis of T. foetus presents important limitations in terms of sensitivity and specificity in bovines. Here, we characterize the plasma membrane proteome of T. foetus and identify proteins that are represented in different isolates of this protozoan. Additionally, we performed a bioinformatic analysis that revealed the antigenicity potential of some of those proteins. This analysis is the first study to identify common proteins at the plasma membrane of different T. foetus isolates that could be targets for alternative diagnostic or vaccine techniques in the future.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2045-2322
Relation:	https://doaj.org/toc/2045-2322
DOI:	10.1038/s41598-024-67827-8
Access URL:	https://doaj.org/article/283cb1119df4474c93fa30a2734607f3
Accession Number:	edsdoj.283cb1119df4474c93fa30a2734607f3
Database:	Directory of Open Access Journals
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More Details
ISSN:	20452322
DOI:	10.1038/s41598-024-67827-8
Published in:	Scientific Reports
Language:	English