Effects of vitamin D3 supplementation on the recovery of hospitalized burn patients: a randomized double-blind controlled trial

Bibliographic Details
Title: Effects of vitamin D3 supplementation on the recovery of hospitalized burn patients: a randomized double-blind controlled trial
Authors: Elahe Ghadimi, Roozbeh Rahbar, Elham Jafarzade, Anahita Mansoori
Source: BMC Nutrition, Vol 11, Iss 1, Pp 1-11 (2025)
Publisher Information: BMC, 2025.
Publication Year: 2025
Collection: LCC:Nutrition. Foods and food supply
LCC:Food processing and manufacture
LCC:Medicine (General)
Subject Terms: Burn patients, Vitamin D supplementation, Wound healing, Wound infection, Scar formation, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456, Medicine (General), R5-920
More Details: Abstract Background Burn patients, due to their damaged skin, may not be able to synthesize vitamin D. In this study, we aimed to evaluate the effects of vitamin D supplementation on the recovery of hospitalized burn patients. Methods Fifty-four patients participated in a randomized controlled trial. Eighteen patients were randomly assigned to group C (control, received gelatin soft gel as placebo), 18 patients to group D1 (received 1000 IU/day vitamin D), and 18 patients to group D2 (received 3000 IU/day vitamin D). After supplementation, wound biopsy and blood samples were obtained from the patients. Weight, height, 25(OH)D level, wound healing, scar formation, quality of pain, and blood parameters were evaluated. Results There were no significant differences in the serum vitamin D levels between the groups at admission (P = 0.52), and 81.5% of the participants were deficient, with a noteworthy increase during study in supplemented groups (P
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2055-0928
Relation: https://doaj.org/toc/2055-0928
DOI: 10.1186/s40795-025-01024-2
Access URL: https://doaj.org/article/27eb60fd263942448d201214adb277b0
Accession Number: edsdoj.27eb60fd263942448d201214adb277b0
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  Data: <searchLink fieldCode="AR" term="%22Elahe+Ghadimi%22">Elahe Ghadimi</searchLink><br /><searchLink fieldCode="AR" term="%22Roozbeh+Rahbar%22">Roozbeh Rahbar</searchLink><br /><searchLink fieldCode="AR" term="%22Elham+Jafarzade%22">Elham Jafarzade</searchLink><br /><searchLink fieldCode="AR" term="%22Anahita+Mansoori%22">Anahita Mansoori</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Burn+patients%22">Burn patients</searchLink><br /><searchLink fieldCode="DE" term="%22Vitamin+D+supplementation%22">Vitamin D supplementation</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+infection%22">Wound infection</searchLink><br /><searchLink fieldCode="DE" term="%22Scar+formation%22">Scar formation</searchLink><br /><searchLink fieldCode="DE" term="%22Nutrition%2E+Foods+and+food+supply%22">Nutrition. Foods and food supply</searchLink><br /><searchLink fieldCode="DE" term="%22TX341-641%22">TX341-641</searchLink><br /><searchLink fieldCode="DE" term="%22Food+processing+and+manufacture%22">Food processing and manufacture</searchLink><br /><searchLink fieldCode="DE" term="%22TP368-456%22">TP368-456</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine+%28General%29%22">Medicine (General)</searchLink><br /><searchLink fieldCode="DE" term="%22R5-920%22">R5-920</searchLink>
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  Data: Abstract Background Burn patients, due to their damaged skin, may not be able to synthesize vitamin D. In this study, we aimed to evaluate the effects of vitamin D supplementation on the recovery of hospitalized burn patients. Methods Fifty-four patients participated in a randomized controlled trial. Eighteen patients were randomly assigned to group C (control, received gelatin soft gel as placebo), 18 patients to group D1 (received 1000 IU/day vitamin D), and 18 patients to group D2 (received 3000 IU/day vitamin D). After supplementation, wound biopsy and blood samples were obtained from the patients. Weight, height, 25(OH)D level, wound healing, scar formation, quality of pain, and blood parameters were evaluated. Results There were no significant differences in the serum vitamin D levels between the groups at admission (P = 0.52), and 81.5% of the participants were deficient, with a noteworthy increase during study in supplemented groups (P
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    Subjects:
      – SubjectFull: Burn patients
        Type: general
      – SubjectFull: Vitamin D supplementation
        Type: general
      – SubjectFull: Wound healing
        Type: general
      – SubjectFull: Wound infection
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      – SubjectFull: Scar formation
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