Bibliographic Details
| Title: |
Ecological effects of cefepime use during antibiotic cycling on the Gram-negative enteric flora of ICU patients |
| Authors: |
Carola Venturini, Andrew N. Ginn, Brooke E. Wilson, Guy Tsafnat, Ian Paulsen, Sally R. Partridge, Jonathan R. Iredell |
| Source: |
Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-7 (2018) |
| Publisher Information: |
SpringerOpen, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Medical emergencies. Critical care. Intensive care. First aid |
| Subject Terms: |
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| More Details: |
Abstract This study examines the impact of cefepime and APP-β (antipseudomonal penicillin/ β-lactamase inhibitor combinations) on Gram-negative bacterial colonization and resistance in two Australian ICUs. While resistance did not cumulatively increase, cefepime (but not APP-β treatment) was associated with acquisition of antibiotic resistant Enterobacteriaceae, consistent with an ecological effect. Analysis of the resident gut E. coli population in a subset of patients showed an increase in markers of horizontal gene transfer after cefepime exposure that helps explain the increase in APP-β resistance and reminds us that unmeasured impacts on the microbiome are key outcome determinants that need to be fully explored. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2197-425X |
| Relation: |
http://link.springer.com/article/10.1186/s40635-018-0185-2; https://doaj.org/toc/2197-425X |
| DOI: |
10.1186/s40635-018-0185-2 |
| Access URL: |
https://doaj.org/article/ae277a722a524a168066e54b7f45db00 |
| Accession Number: |
edsdoj.277a722a524a168066e54b7f45db00 |
| Database: |
Directory of Open Access Journals |
