| Title: |
Sarilumab Administration in COVID-19 Patients: Literature Review and Considerations |
| Authors: |
Andrea Marino, Antonio Munafò, Egle Augello, Carlo Maria Bellanca, Carmelo Bonomo, Manuela Ceccarelli, Nicolò Musso, Giuseppina Cantarella, Bruno Cacopardo, Renato Bernardini |
| Source: |
Infectious Disease Reports, Vol 14, Iss 3, Pp 360-371 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Other systems of medicine |
| Subject Terms: |
COVID-19, cytokines, IL-6, IL-6R, sarilumab, Other systems of medicine, RZ201-999 |
| More Details: |
Two years have passed since WHO declared a pandemic state for SARS-CoV-2 infection. COVID-19 pathogenesis consists of a first viral phase responsible for early symptoms followed by an inflammatory phase, cytokine-mediated, responsible for late-onset manifestations up to ARDS. The dysregulated immune response has an outstanding role in the progression of pulmonary damage in COVID-19. IL-6, through the induction of pro-inflammatory chemokines and cytokines, plays a key role in the development and maintenance of inflammation, acting as a pioneer of the hyperinflammatory condition and cytokine storm in severe COVID-19. Therefore, drugs targeting both IL-6 and IL-6 receptors have been evaluated in order to blunt the abnormal SARS-CoV-2-induced cytokine release. Sarilumab, a high-affinity anti-IL-6 receptor antibody, may represent a promising weapon to treat the fearsome hyperinflammatory phase by improving the outcome of patients with moderate-to-severe COVID-19 pneumonia. Further prospective and well-designed clinical studies with larger sample sizes and long-term follow-up are needed to assess the efficacy and the safety of this therapeutic approach to achieve improved outcomes in COVID-19. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2036-7449 |
| Relation: |
https://www.mdpi.com/2036-7449/14/3/40; https://doaj.org/toc/2036-7449 |
| DOI: |
10.3390/idr14030040 |
| Access URL: |
https://doaj.org/article/27427e1e8836400083c48ab7fd070f83 |
| Accession Number: |
edsdoj.27427e1e8836400083c48ab7fd070f83 |
| Database: |
Directory of Open Access Journals |
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