Bibliographic Details
| Title: |
Multiple intracellular pathogen infections with ocular pathologies associated with adult-onset immunodeficiency due to anti-interferon-γ autoantibodies: a case report |
| Authors: |
Yan Ning, Qingliang Yu, Hanlin Liang, Siyao Wu, Siqiao Liang, Xiaona Liang, Zhiyi He |
| Source: |
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-5 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Anti-interferon-γ autoantibodies, Nontuberculous mycobacteria, Talaromyces marneffei, Mycobacterium tuberculosis, Case report, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Abstract Background Autoantibodies against interferon-γ (IFN-γ) can inhibit IFN-γ-dependent signal transducer and activator of transcription 1 phosphorylation and thus increase the risk of infection with intracellular pathogens, such as Talaromyces marneffei (TM), nontuberculous mycobacteria (NTMs), and Mycobacterium tuberculosis (TB). Here, we report a rare case of triple infection caused by TM, NTM, and TB in a human immunodeficiency virus–negative patient. Case presentation A middle-aged female was admitted to our hospital after experiencing recurrent rash, cough, and expectoration for 4 months. She was successively diagnosed with NTM, TM, and TB infections without conventional immunosuppression-associated factors. However, after effective anti-infective treatment, the patient was confirmed to have allergic conjunctivitis and was successfully treated with corticosteroids and immunosuppressants. The most conspicuous characteristics were recurrent infection and immune disorders. Conclusions High-titer anti-IFN-γ autoantibodies are strongly associated with severe and disseminated infections, such as NTM, TM, and TB. It is characterized by persistently high degree of inflammation and high immunoglobin levels. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2334 |
| Relation: |
https://doaj.org/toc/1471-2334 |
| DOI: |
10.1186/s12879-024-09003-x |
| Access URL: |
https://doaj.org/article/2735102cc4614323a0f0d038f972ffea |
| Accession Number: |
edsdoj.2735102cc4614323a0f0d038f972ffea |
| Database: |
Directory of Open Access Journals |
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