Academic Journal
Pharmacological manipulation of macrophage autophagy effectively rejuvenates the regenerative potential of biodegrading vascular graft in aging body
| Title: | Pharmacological manipulation of macrophage autophagy effectively rejuvenates the regenerative potential of biodegrading vascular graft in aging body |
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| Authors: | Wanli Chen, Weiwei Xiao, Xuzheng Liu, Pingping Yuan, Siqian Zhang, Yinggang Wang, Wei Wu |
| Source: | Bioactive Materials, Vol 11, Iss , Pp 283-299 (2022) |
| Publisher Information: | KeAi Communications Co., Ltd., 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| Subject Terms: | Autophagy, Macrophages, Inflammation, Aging, Fast-degradation materials, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| More Details: | Declined regenerative potential and aggravated inflammation upon aging create an inappropriate environment for arterial regeneration. Macrophages are one of vital effector cells in the immune microenvironment, especially during biomaterials mediated repairing process. Here, we revealed that the macrophage autophagy decreased with aging, which led to aggravated inflammation, thereby causing poor vascular remodeling of artificial grafts in aging body. Through loading the autophagy-targeted drugs, rapamycin and 3-MA (3-methyladenine), in PCL (polycaprolactone) sheath of the PGS (poly glycerol sebacate) - PCL vascular graft, the essential role of macrophage autophagy was confirmed in regulating macrophage polarization and biomaterial degradation. Moreover, the utilization of rapamycin promoted anti-inflammatory polarization of macrophage by activating autophagy, which further promoted myogenic differentiation of vascular progenitor cells and accelerated endothelialization. Our study elucidated the contribution of pharmacological manipulation of macrophage autophagy in promoting regeneration of small caliber artery, which may pave a new avenue for clinical translation of vascular grafts in aging body. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X2100445X; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2021.09.027 |
| Access URL: | https://doaj.org/article/267b4329891b412e982990e87f03aa45 |
| Accession Number: | edsdoj.267b4329891b412e982990e87f03aa45 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2021.09.027 |
| Published in: | Bioactive Materials |
| Language: | English |