Bibliographic Details
| Title: |
In vitro and in vivo evaluation of electrochemotherapy with trans-platinum analogue trans-[PtCl2(3-Hmpy)2] |
| Authors: |
Kranjc Simona, Cemazar Maja, Sersa Gregor, Scancar Janez, Grabner Sabina |
| Source: |
Radiology and Oncology, Vol 51, Iss 3, Pp 295-306 (2017) |
| Publisher Information: |
Sciendo, 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Medical physics. Medical radiology. Nuclear medicine |
| Subject Terms: |
platinum analogue, cisplatin, 3-hmpy, electroporation, electrochemotherapy, mouse sarcoma, Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| More Details: |
Cisplatin is used in cancer therapy, but its side effects and acquired resistance to cisplatin have led to the synthesis and evaluation of new platinum compounds. Recently, the synthesized platinum compound trans-[PtCl2(3-Hmpy)2] (3-Hmpy = 3-hydroxymethylpyridine) (compound 2) showed a considerable cytotoxic and antitumour effectiveness. To improve compound 2 cytotoxicity in vitro and antitumour effectiveness in vivo, electroporation was used as drug delivery approach to increase membrane permeability (electrochemotherapy). |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1581-3207 |
| Relation: |
https://doaj.org/toc/1581-3207 |
| DOI: |
10.1515/raon-2017-0034 |
| Access URL: |
https://doaj.org/article/2674816da4874419b84863c7919d9ad1 |
| Accession Number: |
edsdoj.2674816da4874419b84863c7919d9ad1 |
| Database: |
Directory of Open Access Journals |
