Bibliographic Details
| Title: |
Structural elucidation of a novel arabinogalactan LFP-80-W1 from Lycii fructus with potential immunostimulatory activity |
| Authors: |
Xiaofei Liang, Mengqiu Liu, Sheng Guo, Fang Zhang, Wanchen Cui, Fei Zeng, Mingming Xu, Dawei Qian, Jinao Duan |
| Source: |
Frontiers in Nutrition, Vol 9 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
Lycii fructus, polysaccharide, arabinogalactan, structural elucidation, immunomodulatory activity, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
Polysaccharides are the most important effective components of Lycii fructus, which has a variety of biological activities and broad application prospects in the fields of medicine and food. In this study, we reported a novel arabinogalactan LFP-80-W1 with potential immunostimulatory activity. LFP-80-W1 was a continuous symmetrical single-peak with an average molecular weight of 4.58 × 104 Da and was mainly composed of arabinose and galactose. Oligosaccharide sequencing analyses and NMR data showed that the LFP-80-W1 domain consists of a repeated 1,6-linked β-Galp main chain with branches arabinoglycan and arabinogalactan at position C-3. Importantly, we found that LFP-80-W1 could activate the MAPK pathway and promote the release of NO, IL-6, and TNF-α cytokines in vitro. Therefore, our findings suggest that the homogeneous arabinogalactan from Lycii fructus, can be used as a natural immunomodulator. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-861X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnut.2022.1067836/full; https://doaj.org/toc/2296-861X |
| DOI: |
10.3389/fnut.2022.1067836 |
| Access URL: |
https://doaj.org/article/26505227c8d340798383795fdb0d323e |
| Accession Number: |
edsdoj.26505227c8d340798383795fdb0d323e |
| Database: |
Directory of Open Access Journals |
