Significance of descriptive symptoms and signs and clinical parameters as predictors of neuropathic cancer pain.

Bibliographic Details
Title: Significance of descriptive symptoms and signs and clinical parameters as predictors of neuropathic cancer pain.
Authors: Sun Kyung Baek, Sang Won Shin, Su-Jin Koh, Jung Han Kim, Hyo Jung Kim, Byoung Yong Shim, Seok Yun Kang, Sang Byung Bae, Hwan Jung Yun, Sun Jin Sym, Hye Sook Han, Ha Yeong Gil
Source: PLoS ONE, Vol 16, Iss 8, p e0252781 (2021)
Publisher Information: Public Library of Science (PLoS), 2021.
Publication Year: 2021
Collection: LCC:Medicine
LCC:Science
Subject Terms: Medicine, Science
More Details: PurposeEvaluation of symptoms and signs for the management of neuropathic cancer pain (NCP) is challenging. This study aimed to identify clinical predictors of NCP and symptoms and signs most relevant of those in Korean patients.MethodsThis nationwide, descriptive, cross-sectional, multicenter, observational study included 2,003 cancer patients aged ≥20 years who reported a visual analog scale (VAS) score ≥1 for pain and provided informed consent for participation. The Douleur Neuropathic (DN4) questionnaire (score ≥4) was used to determine symptoms and signs as well as the presence of NCP.ResultsThe prevalence of NCP was associated with age 6 months (OR, 1.57; 95% CI, 1.232-2.012), stage IV cancer (OR, 0.75; 95% CI, 0.593-0.955), history of chemotherapy (OR, 1.74; 95% CI, 1.225-2.472), and moderate-to-severe cancer pain (OR, 2.05; 95% CI, 1.671-2.524) after multivariate analysis. The most common descriptive symptoms of NCP were tingling, electric shock, and pins and needles. For NCP patients in the presence or absence of the clinical predictors, pins and needles (p = 0.001) and painful cold (pConclusionAge 6 months, stage IV cancer, history of chemotherapy, and moderate-to-severe cancer pain, were identified as predictors of NCP. Some symptoms and signs of NCP were associated with these predictors. Further studies are warranted on the pathogenesis and management of NCP with respect to the symptoms and signs, and factors associated with pain severity in Korean patients.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0252781
Access URL: https://doaj.org/article/2644a01c5fca4ba3a74a578eb0ccf045
Accession Number: edsdoj.2644a01c5fca4ba3a74a578eb0ccf045
Database: Directory of Open Access Journals
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More Details
ISSN:19326203
DOI:10.1371/journal.pone.0252781
Published in:PLoS ONE
Language:English