Academic Journal
Neuroanatomical correlates of Klinefelter syndrome studied in relation to the neuropsychological profile
| Title: | Neuroanatomical correlates of Klinefelter syndrome studied in relation to the neuropsychological profile |
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| Authors: | Anne Skakkebæk, Claus Højbjerg Gravholt, Peter Mondrup Rasmussen, Anders Bojesen, Jens Søndergaard Jensen, Jens Fedder, Peter Laurberg, Jens Michael Hertz, John Rosendahl Østergaard, Anders Degn Pedersen, Mikkel Wallentin |
| Source: | NeuroImage: Clinical, Vol 4, Iss C, Pp 1-9 (2014) |
| Publisher Information: | Elsevier, 2014. |
| Publication Year: | 2014 |
| Collection: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | Klinefelter syndrome, MRI, Cognition, Personality, Mental disorders, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Brain imaging in Klinefelter syndrome (47, XXY) (KS), a genetic disorder characterized by the presence of an extra X chromosome, may contribute to understanding the relationship between gene expression, brain structure, and subsequent cognitive disabilities and psychiatric disorders. We conducted the largest to date voxel-based morphometry study of 65 KS subjects and 65 controls matched for age and education and correlated these data to neuropsychological test scores. The KS patients had significantly smaller total brain volume (TBV), total gray matter volume (GMV) and total white matter volume (WMV) compared to controls, whereas no volumetric difference in cerebral spinal fluid (CSF) was found. There were no differences in TBV, GMV, WMV or CSF between testosterone treated KS (T-KS) and untreated KS (U-KS) patients. Compared to controls, KS patients had significantly decreased GMV bilaterally in insula, putamen, caudate, hippocampus, amygdala, temporal pole and frontal inferior orbita. Additionally, the right parahippocampal region and cerebellar volumes were reduced in KS patients. KS patients had significantly larger volumes in right postcentral gyrus, precuneus and parietal regions. Multivariate classification analysis discriminated KS patients from controls with 96.9% (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158213001435; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2013.10.013 |
| Access URL: | https://doaj.org/article/263c272099474c38b45ae92fb346e133 |
| Accession Number: | edsdoj.263c272099474c38b45ae92fb346e133 |
| Database: | Directory of Open Access Journals |
| ISSN: | 22131582 |
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| DOI: | 10.1016/j.nicl.2013.10.013 |
| Published in: | NeuroImage: Clinical |
| Language: | English |