Bibliographic Details
| Title: |
Dietary n-3 LCPUFA from fish oil but not α-linolenic acid-derived LCPUFA confers atheroprotection in mice[S] |
| Authors: |
Chiara Degirolamo, Kathryn L. Kelley, Martha D. Wilson, Lawrence L. Rudel |
| Source: |
Journal of Lipid Research, Vol 51, Iss 7, Pp 1897-1905 (2010) |
| Publisher Information: |
Elsevier, 2010. |
| Publication Year: |
2010 |
| Collection: |
LCC:Biochemistry |
| Subject Terms: |
atherosclerosis, cholesteryl ester, lipoprotein metabolism, liver, long chain polyunsaturated fatty acid, Biochemistry, QD415-436 |
| More Details: |
The atheroprotective potential of n-3 α-linolenic acid (ALA) has not yet been fully determined, even in murine models of atherosclerosis. We tested whether ALA-derived, n-3 long chain polyunsaturated fatty acids (LCPUFA) could offer atheroprotection in a dose-dependent manner. Apolipoprotein B (ApoB)100/100LDLr−/− mice were fed with diets containing two levels of ALA from flaxseed oil for 16 weeks. Fish oil- and cis-monounsaturated-fat-enriched diets were used as positive and negative controls, respectively. The mice fed cis-monounsaturated fat and ALA-enriched diets exhibited equivalent plasma total cholesterol (TPC) and LDL-cholesterol (LDL-c) levels; only mice fed the fish-oil diet had lower TPC and LDL-c concentrations. Plasma LDL-CE fatty acid composition analysis showed that ALA-enriched diets lowered the percentage of atherogenic cholesteryl oleate compared with cis-monounsaturated-fat diet (44% versus 55.6%) but not as efficiently as the fish-oil diet (32.4%). Although both ALA and fish-oil diets equally enriched hepatic phospholipids with eicosapentaenoic acid (EPA) and ALA-enriched diets lowered hepatic cholesteryl ester (CE) levels compared with cis-monounsaturated-fat diet, only fish oil strongly protected from atherosclerosis. These outcomes indicate that dietary n-3 LCPUFA from fish oil and n-3 LCPUFA (mostly EPA) synthesized endogenously from ALA were not equally atheroprotective in these mice. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
0022-2275 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0022227520371121; https://doaj.org/toc/0022-2275 |
| DOI: |
10.1194/jlr.M005058 |
| Access URL: |
https://doaj.org/article/2606423c39a34a2e96a4d6d7feaff5a6 |
| Accession Number: |
edsdoj.2606423c39a34a2e96a4d6d7feaff5a6 |
| Database: |
Directory of Open Access Journals |
