Bibliographic Details
| Title: |
Consensus-based statements for the management of mitochondrial stroke-like episodes [version 1; peer review: 2 approved] |
| Authors: |
Yi Shiau Ng, Laurence A. Bindoff, Gráinne S. Gorman, Rita Horvath, Thomas Klopstock, Michelangelo Mancuso, Mika H. Martikainen, Robert Mcfarland, Victoria Nesbitt, Robert D. S. Pitceathly, Andrew M. Schaefer, Doug M. Turnbull |
| Source: |
Wellcome Open Research, Vol 4 (2019) |
| Publisher Information: |
Wellcome, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Background: Focal-onset seizures and encephalopathy are prominent features of a stroke-like episode, which is a severe neurological manifestation associated with subtypes of mitochondrial disease. Despite more than 30 years of research, the acute treatment of stroke-like episodes remains controversial. Methods: We used the modified Delphi process to harness the clinical expertise of a group of mitochondrial disease specialists from five European countries to produce consensus guidance for the acute management of stroke-like episodes and commonly associated complications. Results: Consensus on a new definition of mitochondrial stroke-like episodes was achieved and enabled the group to develop diagnostic criteria based on clinical features, neuroimaging and/or electroencephalogram findings. Guidelines for the management of strokelike episodes were agreed with aggressive seizure management strongly recommended at the outset of stroke-like episodes. Conclusions: Our consensus statement defines stroke-like episodes in terms of an epileptic encephalopathy and we have used this to revise both diagnostic criteria and guidelines for management. A prospective, multi-centre, randomised controlled trial is required for evaluating the efficacy of any compound on modifying the trajectory of stroke-like episodes. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2398-502X |
| Relation: |
https://wellcomeopenresearch.org/articles/4-201/v1; https://doaj.org/toc/2398-502X |
| DOI: |
10.12688/wellcomeopenres.15599.1 |
| Access URL: |
https://doaj.org/article/25b451bec90b4c3ab265f9e6984ed32a |
| Accession Number: |
edsdoj.25b451bec90b4c3ab265f9e6984ed32a |
| Database: |
Directory of Open Access Journals |
