Analysis of allergen positivity rates in relation to gender, age, and cross-reactivity patterns

Bibliographic Details
Title: Analysis of allergen positivity rates in relation to gender, age, and cross-reactivity patterns
Authors: Ben Wang, Di Zhang, Zhihui Jiang, Fang Liu
Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Publisher Information: Nature Portfolio, 2024.
Publication Year: 2024
Collection: LCC:Medicine
LCC:Science
Subject Terms: Allergens, Sensitivity, Gender disparities, Age-related variations, Concurrent reactions, Medicine, Science
More Details: Abstract Objective: This study aims to gain a deeper understanding of the patterns of allergen detection positivity rates among different age and gender groups, and to explore cross-reactivity patterns among allergens. Methods: We conducted a retrospective analysis of patients who underwent allergen testing at our hospital. The sample for this study included all patients who underwent allergen testing. We utilized immune blotting to detect specific IgE antibodies to 20 allergens in patient sera. Results: The study results showed a higher proportion of female samples (72.35%) compared to male samples (27.65%). Among all participants, the age distribution was primarily concentrated in the 25–35 age group, accounting for 37.43% of the total sample, followed by the 45 years and older age group, accounting for 27.00%. This indicates that allergic symptoms may occur not only in children and adolescents but also at any time after adulthood. We further observed significant influences of factors such as gender and age on individual sensitivity to specific allergens. For example, compared to males, females were found to be more sensitive to certain allergens such as cat hair, dust mites, and dog epithelium. Similarly, we also found variations in sensitivity to specific allergens among different age groups. Conclusion: Close monitoring of allergen distribution in populations facilitates active engagement of allergic individuals in self-management, while gender and age may be important factors influencing individual sensitivity to specific allergens. These findings provide valuable insights for understanding the pathogenesis of allergic diseases and designing more effective prevention and treatment strategies.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-78909-y
Access URL: https://doaj.org/article/2596af19179c415babd24433697d5232
Accession Number: edsdoj.2596af19179c415babd24433697d5232
Database: Directory of Open Access Journals
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  Value: <anid>AN0180905578;[fkqs]14nov.24;2024Nov27.13:04;v2.2.500</anid> <title id="AN0180905578-1">Analysis of allergen positivity rates in relation to gender, age, and cross-reactivity patterns </title> <p>Objective: This study aims to gain a deeper understanding of the patterns of allergen detection positivity rates among different age and gender groups, and to explore cross-reactivity patterns among allergens. Methods: We conducted a retrospective analysis of patients who underwent allergen testing at our hospital. The sample for this study included all patients who underwent allergen testing. We utilized immune blotting to detect specific IgE antibodies to 20 allergens in patient sera. Results: The study results showed a higher proportion of female samples (72.35%) compared to male samples (27.65%). Among all participants, the age distribution was primarily concentrated in the 25–35 age group, accounting for 37.43% of the total sample, followed by the 45 years and older age group, accounting for 27.00%. This indicates that allergic symptoms may occur not only in children and adolescents but also at any time after adulthood. We further observed significant influences of factors such as gender and age on individual sensitivity to specific allergens. For example, compared to males, females were found to be more sensitive to certain allergens such as cat hair, dust mites, and dog epithelium. Similarly, we also found variations in sensitivity to specific allergens among different age groups. Conclusion: Close monitoring of allergen distribution in populations facilitates active engagement of allergic individuals in self-management, while gender and age may be important factors influencing individual sensitivity to specific allergens. These findings provide valuable insights for understanding the pathogenesis of allergic diseases and designing more effective prevention and treatment strategies.</p> <p>Keywords: Allergens; Sensitivity; Gender disparities; Age-related variations; Concurrent reactions</p> <hd id="AN0180905578-2">Introduction</hd> <p>Allergic diseases, also referred to as hypersensitivity conditions, encompass a group of disorders in which the body produces specific antibodies in response to antigenic substances, commonly known as allergens[<reflink idref="bib1" id="ref1">1</reflink>]–[<reflink idref="bib3" id="ref2">3</reflink>]. Upon re-exposure to similar antigens, these conditions provoke exaggerated or pathological immune reactions, leading to physiological dysfunction in tissues and organs[<reflink idref="bib4" id="ref3">4</reflink>],[<reflink idref="bib5" id="ref4">5</reflink>]. The prevalence of allergic diseases is notably high across the globe. According to the World Allergy Organization, approximately 22% of the global population suffers from allergic conditions, meaning that one in five individuals worldwide is affected[<reflink idref="bib6" id="ref5">6</reflink>]. In China, the prevalence surpasses 20%, with an estimated affected population exceeding 200 million[<reflink idref="bib7" id="ref6">7</reflink>]. Furthermore, data suggests that nearly 40% of the global population has either experienced or is currently experiencing some form of allergy[<reflink idref="bib8" id="ref7">8</reflink>].</p> <p>Due to the widespread prevalence, wide age range of sufferers, and the challenges associated with treatment—characterized by low efficacy and high recurrence rates—the primary focus of allergic disease management is on prevention[<reflink idref="bib9" id="ref8">9</reflink>],[<reflink idref="bib10" id="ref9">10</reflink>]. Common allergens include foods such as wheat, peanuts, soybeans, nuts, milk, eggs, fish, and shellfish; inhalants such as pollen, house dust, and mites; microorganisms like molds and bacteria; as well as insect toxins, certain drugs such as penicillin and sulfonamides, heterologous serum, and physical factors like cold air, humidity, and friction[<reflink idref="bib11" id="ref10">11</reflink>]–[<reflink idref="bib14" id="ref11">14</reflink>]. Monitoring the distribution of allergens in populations is crucial for allergic individuals, as it aids in effective self-management[<reflink idref="bib15" id="ref12">15</reflink>].</p> <p>Allergen types and concentrations can vary across different regions and even within the same region over time[<reflink idref="bib16" id="ref13">16</reflink>],[<reflink idref="bib17" id="ref14">17</reflink>]. By identifying allergens within a regional population, healthcare providers can gain insight into the allergen distribution in the area, offering a valuable foundation for the prevention and treatment of allergies. In this study, we conducted a retrospective analysis of allergen test results from our hospital between January and November 2023, providing data to support understanding of regional allergen distribution.</p> <hd id="AN0180905578-3">Materials and methods</hd> <p></p> <hd id="AN0180905578-4">Study population</hd> <p>This retrospective analysis included patients who underwent allergen testing at Beijing Chaoyang Hospital, Capital Medical University, from January 2023 to November 2023. The study employed the immunoblot method to detect specific IgE antibodies against 20 allergens in the patients' sera. The characteristics and distribution patterns of allergens were analyzed based on gender, age, and the positive rates of allergen test results, including cross-reactivity. Ethical approval for this study was obtained from the Ethics Committee of Beijing Chaoyang Hospital, Capital Medical University.</p> <hd id="AN0180905578-5">Allergen detection</hd> <p>Serum samples were collected from each patient and stored at -80 °C until analysis. Specific IgE antibodies against 20 allergens, including common inhalants (e.g., house dust mites, pollens, molds, and animal dander) and food allergens, were detected using the immunoblot method. The allergen-specific IgE testing was carried out using the EUROLINE test kit (EUROIMMUN, Lübeck, Germany), following the manufacturer's instructions. Briefly, serum samples were incubated with a nitrocellulose membrane pre-coated with allergen extracts. After washing, a biotin-labeled anti-human IgE antibody was added, followed by incubation with streptavidin-alkaline phosphatase. The immunoblot strips were then developed using a chromogenic substrate, and the color intensity of each band corresponding to specific allergens was measured using dedicated EUROLineScan software. The results were interpreted based on the intensity of the bands, categorized into classes ranging from 0 to 2, where class 0 represents no detectable IgE, and classes 1 to 2 indicate increasing levels of specific IgE. For each patient, a result of class 1 or above was considered positive for the corresponding allergen.</p> <hd id="AN0180905578-6">Inclusion and exclusion criteria</hd> <p>Inclusion Criteria: Patients with complete demographic information who underwent allergen testing at our hospital from January 2023 to November 2023. Exclusion Criteria: None.</p> <hd id="AN0180905578-7">Statistical analysis</hd> <p>Data processing was performed using IBM SPSS Statistics 21 software, and graphical representations were created using Microsoft Office Excel 2019. The Chi-square test was employed to compare differences among different genders, age groups, and allergy diagnoses. In cases where the sample size was small or the data did not meet the prerequisites for the Chi-square test, Fisher's Exact Test was used to assess differences between two categorical variables. Network clustering diagrams were generated using R version 4.1.1 software (R Core Team, 2021), utilizing the pheatmap package for heatmap procedures and the igraph package for network procedures. A p-value < 0.05 was considered statistically significant.</p> <hd id="AN0180905578-8">Results</hd> <p></p> <hd id="AN0180905578-9">Overview of allergen detection results</hd> <p>Table 1 presents the frequency and cumulative frequency of different allergen detection results, alongside their respective variable levels. In terms of gender distribution, the number of female samples (72.35%) substantially exceeds that of males (27.65%). The age distribution shows a predominance of the 25–35 age group, constituting 37.43% of the total sample, followed by the 45 years and older age group, comprising 27.00%. When grouped by age, using 35 years as the boundary, 53.07% of the samples are below 35 years old, while 46.93% are 35 years or older. September emerges as the month with the highest sample count, representing 15.83% of the total. Most samples (69.83%) exhibit a negative reaction to allergens, while positive reactions to one allergen and two or more allergens constitute 14.80% and 15.36%, respectively. The top 10 allergens ranked by their combined weak and strong positivity rates are as follows: Cat Hair (9.87%), House Dust Mite, Powder Mite (9.50%), Artemisia (9.31%), Chicken Egg White (3.80%), Dog Epithelium (3.91%), Ryegrass (3.54%), House Dust (4.75%), Willow Tree, Poplar Tree, Elm Tree (2.79%), Crab (2.51%), and Lamb (2.24%).</p> <p>Table 1 Detailed allergen statistics and frequency distribution data.</p> <p> <ephtml> <table frame="hsides" rules="groups"><thead><tr><th align="left"><p>Variable Name</p></th><th align="left"><p>Variable Level</p></th><th align="left"><p>Frequency (%)</p></th><th align="left"><p>Cumulative Frequency (%)</p></th></tr></thead><tbody><tr><td align="left"><p>Gender</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>297 (27.65)</p></td><td char="." align="char"><p>297 (27.65)</p></td></tr><tr><td align="left" /><td align="left"><p>Female</p></td><td char="." align="char"><p>777 (72.35)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Age Group</p></td><td align="left"><p>< 25 years old</p></td><td char="." align="char"><p>168 (15.64)</p></td><td char="." align="char"><p>168 (15.64)</p></td></tr><tr><td align="left" /><td align="left"><p>25–35 years old</p></td><td char="." align="char"><p>402 (37.43)</p></td><td char="." align="char"><p>570 (53.07)</p></td></tr><tr><td align="left" /><td align="left"><p>35–45 years old</p></td><td char="." align="char"><p>214 (19.93)</p></td><td char="." align="char"><p>784 (73.00)</p></td></tr><tr><td align="left" /><td align="left"><p>≥ 45 years old</p></td><td char="." align="char"><p>290 (27.00)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Age Group</p></td><td align="left"><p>< 35 years old</p></td><td char="." align="char"><p>570 (53.07)</p></td><td char="." align="char"><p>570 (53.07)</p></td></tr><tr><td align="left" /><td align="left"><p>≥ 35 years old</p></td><td char="." align="char"><p>504 (46.93)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Detection Month</p></td><td align="left"><p>3</p></td><td char="." align="char"><p>103 (9.59)</p></td><td char="." align="char"><p>103 (9.59)</p></td></tr><tr><td align="left" /><td align="left"><p>4</p></td><td char="." align="char"><p>134 (12.48)</p></td><td char="." align="char"><p>237 (22.07)</p></td></tr><tr><td align="left" /><td align="left"><p>5</p></td><td char="." align="char"><p>184 (17.13)</p></td><td char="." align="char"><p>421 (39.20)</p></td></tr><tr><td align="left" /><td align="left"><p>6</p></td><td char="." align="char"><p>150 (13.97)</p></td><td char="." align="char"><p>571 (53.17)</p></td></tr><tr><td align="left" /><td align="left"><p>7</p></td><td char="." align="char"><p>183 (17.04)</p></td><td char="." align="char"><p>754 (70.20)</p></td></tr><tr><td align="left" /><td align="left"><p>8</p></td><td char="." align="char"><p>150 (13.97)</p></td><td char="." align="char"><p>904 (84.17)</p></td></tr><tr><td align="left" /><td align="left"><p>9</p></td><td char="." align="char"><p>170 (15.83)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Allergen Count</p></td><td align="left"><p>Negative</p></td><td char="." align="char"><p>750 (69.83)</p></td><td char="." align="char"><p>750 (69.83)</p></td></tr><tr><td align="left" /><td align="left"><p>1 kind</p></td><td char="." align="char"><p>159 (14.80)</p></td><td char="." align="char"><p>909 (84.64)</p></td></tr><tr><td align="left" /><td align="left"><p>2 or more kinds</p></td><td char="." align="char"><p>165 (15.36)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Diagnosis</p></td><td align="left"><p>Allergic dermatitis</p></td><td char="." align="char"><p>259 (24.12)</p></td><td char="." align="char"><p>259 (24.12)</p></td></tr><tr><td align="left" /><td align="left"><p>Other</p></td><td char="." align="char"><p>346 (32.22)</p></td><td char="." align="char"><p>605 (56.33)</p></td></tr><tr><td align="left" /><td align="left"><p>Eczema</p></td><td char="." align="char"><p>149 (13.87)</p></td><td char="." align="char"><p>754 (70.20)</p></td></tr><tr><td align="left" /><td align="left"><p>Urticaria</p></td><td char="." align="char"><p>320 (29.80)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>CCD Marker</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1066 (99.26)</p></td><td char="." align="char"><p>1066 (99.26)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>4 (0.37)</p></td><td char="." align="char"><p>1070 (99.63)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>4 (0.37)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Artemisia</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>974 (90.69)</p></td><td char="." align="char"><p>974 (90.69)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>20 (1.86)</p></td><td char="." align="char"><p>994 (92.55)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>80 (7.45)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Point Mold, Branch Mold, Tobacco Mold, Crosslink Mold</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1062 (98.88)</p></td><td char="." align="char"><p>1062 (98.88)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>9 (0.84)</p></td><td char="." align="char"><p>1071 (99.72)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>3 (0.28)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Dog Epithelium</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1032 (96.09)</p></td><td char="." align="char"><p>1032 (96.09)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>10 (0.93)</p></td><td char="." align="char"><p>1042 (97.02)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>32 (2.98)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Peanuts</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1062 (98.88)</p></td><td char="." align="char"><p>1062 (98.88)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>10 (0.93)</p></td><td char="." align="char"><p>1072 (99.81)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>2 (0.19)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Soybean</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1063 (98.98)</p></td><td char="." align="char"><p>1063 (98.98)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>8 (0.74)</p></td><td char="." align="char"><p>1071 (99.72)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>3 (0.28)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Chicken egg white</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1044 (97.21)</p></td><td char="." align="char"><p>1044 (97.21)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>25 (2.33)</p></td><td char="." align="char"><p>1069 (99.53)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>5 (0.47)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Willow Tree, Poplar Tree, Elm Tree</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1044 (97.21)</p></td><td char="." align="char"><p>1044 (97.21)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>13 (1.21)</p></td><td char="." align="char"><p>1057 (98.42)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>17 (1.58)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Cat Hair</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>968 (90.13)</p></td><td char="." align="char"><p>968 (90.13)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>23 (2.14)</p></td><td char="." align="char"><p>991 (92.27)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>83 (7.73)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Milk</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1063 (98.98)</p></td><td char="." align="char"><p>1063 (98.98)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>4 (0.37)</p></td><td char="." align="char"><p>1067 (99.35)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>7 (0.65)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Beef</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1065 (99.16)</p></td><td char="." align="char"><p>1065 (99.16)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>6 (0.56)</p></td><td char="." align="char"><p>1071 (99.72)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>3 (0.28)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Common Pigweed</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1041 (96.93)</p></td><td char="." align="char"><p>1041 (96.93)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>17 (1.58)</p></td><td char="." align="char"><p>1058 (98.51)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>16 (1.49)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Ryegrass</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1036 (96.46)</p></td><td char="." align="char"><p>1036 (96.46)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>12 (1.12)</p></td><td char="." align="char"><p>1048 (97.58)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>26 (2.42)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>House Dust</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1023 (95.25)</p></td><td char="." align="char"><p>1023 (95.25)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>16 (1.49)</p></td><td char="." align="char"><p>1039 (96.74)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>35 (3.26)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>House Dust Mite, Powder Mite</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>972 (90.50)</p></td><td char="." align="char"><p>972 (90.50)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>23 (2.14)</p></td><td char="." align="char"><p>995 (92.64)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>79 (7.36)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Shrimp</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1065 (99.16)</p></td><td char="." align="char"><p>1065 (99.16)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>3 (0.28)</p></td><td char="." align="char"><p>1068 (99.44)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>6 (0.56)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Crab</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1047 (97.49)</p></td><td char="." align="char"><p>1047 (97.49)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>13 (1.21)</p></td><td char="." align="char"><p>1060 (98.70)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>14 (1.30)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Lamb</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1050 (97.77)</p></td><td char="." align="char"><p>1050 (97.77)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>15 (1.40)</p></td><td char="." align="char"><p>1065 (99.16)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>9 (0.84)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Cockroach</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1057 (98.42)</p></td><td char="." align="char"><p>1057 (98.42)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>13 (1.21)</p></td><td char="." align="char"><p>1070 (99.63)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>4 (0.37)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr><tr><td align="left"><p>Codfish, Lobster, Scallop</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>1061 (98.79)</p></td><td char="." align="char"><p>1061 (98.79)</p></td></tr><tr><td align="left" /><td align="left"><p>2 Weak Positive</p></td><td char="." align="char"><p>10 (0.93)</p></td><td char="." align="char"><p>1071 (99.72)</p></td></tr><tr><td align="left" /><td align="left"><p>3 Strong Positive</p></td><td char="." align="char"><p>3 (0.28)</p></td><td char="." align="char"><p>1074 (100.0)</p></td></tr></tbody></table> </ephtml> </p> <p>CCD, Cross-Reactive Carbohydrate Determinants.</p> <hd id="AN0180905578-10">Gender disparities in allergen sensitivity</hd> <p>Our study observed significant differences in sensitivity to various allergens between males and females (Table 2). Regarding age grading, a statistically significant difference in allergen sensitivity between males and females was found (χ<sups>2</sups> = 8.778, <emph>P</emph> = 0.032). Additionally, a statistically significant difference in the distribution of allergic dermatitis between males and females was observed (χ<sups>2</sups> = 20.587, <emph>P</emph> = 0.000). Furthermore, significant differences in sensitivity to Penicillium, Aspergillus, and related fungi were found between males and females (<emph>P</emph> = 0.024). Gender-based differences in sensitivity to the milk allergen also exhibited statistical significance (<emph>P</emph> = 0.041). Likewise, sensitivity to herbaceous plant allergens showed statistically significant differences between males and females (χ<sups>2</sups> = 4.112, <emph>P</emph> = 0.043). Lastly, significant differences in sensitivity to house dust mite allergens between males and females were noted (χ<sups>2</sups> = 15.270, <emph>P</emph> = 0.000). These findings provide valuable insights into the distribution of allergens among different genders, contributing to a better understanding of allergen profiles.</p> <p>Table 2 Distribution of Allergen Sensitivity among male and female subjects.</p> <p> <ephtml> <table frame="hsides" rules="groups"><thead><tr><th align="left"><p>Variable</p></th><th align="left"><p>Variable level</p></th><th align="left"><p>Male</p></th><th align="left"><p>Female</p></th><th align="left"><p>Row total</p></th><th align="left"><p>Total missing</p></th><th align="left"><p>Test method</p></th><th align="left"><p>Statistical value (χ<sup>2</sup>)</p></th><th align="left"><p><italic>P</italic> value</p></th></tr></thead><tbody><tr><td align="left"><p>Age grading</p></td><td align="left"><p>1 < 25 years</p></td><td char="." align="char"><p>45 (15.15)</p></td><td char="." align="char"><p>123 (15.83)</p></td><td char="." align="char"><p>168 (15.64)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>8.778</p></td><td char="." align="char"><p>0.032</p></td></tr><tr><td align="left" /><td align="left"><p>2 25–35 years</p></td><td char="." align="char"><p>95 (31.99)</p></td><td char="." align="char"><p>307 (39.51)</p></td><td char="." align="char"><p>402 (37.43)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left" /><td align="left"><p>3 35–45 years</p></td><td char="." align="char"><p>59 (19.87)</p></td><td char="." align="char"><p>155 (19.95)</p></td><td char="." align="char"><p>214 (19.93)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left" /><td align="left"><p>4 ≥ 45 years</p></td><td char="." align="char"><p>98 (33.00)</p></td><td char="." align="char"><p>192 (24.71)</p></td><td char="." align="char"><p>290 (27.00)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Number of allergens</p></td><td align="left"><p>A Negative</p></td><td char="." align="char"><p>203 (68.35)</p></td><td char="." align="char"><p>547 (70.40)</p></td><td char="." align="char"><p>750 (69.83)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.708</p></td><td char="." align="char"><p>0.702</p></td></tr><tr><td align="left" /><td align="left"><p>B 1 kind</p></td><td char="." align="char"><p>44 (14.81)</p></td><td char="." align="char"><p>115 (14.80)</p></td><td char="." align="char"><p>159 (14.80)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left" /><td align="left"><p>C 2 or more</p></td><td char="." align="char"><p>50 (16.84)</p></td><td char="." align="char"><p>115 (14.80)</p></td><td char="." align="char"><p>165 (15.36)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Allergy (Total)</p></td><td align="left"><p>A Negative</p></td><td char="." align="char"><p>203 (68.35)</p></td><td char="." align="char"><p>547 (70.40)</p></td><td char="." align="char"><p>750 (69.83)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.428</p></td><td char="." align="char"><p>0.513</p></td></tr><tr><td align="left" /><td align="left"><p>B Positive</p></td><td char="." align="char"><p>94 (31.65)</p></td><td char="." align="char"><p>230 (29.60)</p></td><td char="." align="char"><p>324 (30.17)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Diagnosis</p></td><td align="left"><p>Allergic dermatitis</p></td><td char="." align="char"><p>47 (15.82)</p></td><td char="." align="char"><p>212 (27.28)</p></td><td char="." align="char"><p>259 (24.12)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>20.587</p></td><td char="." align="char"><p>0.000</p></td></tr><tr><td align="left" /><td align="left"><p>Other</p></td><td char="." align="char"><p>106 (35.69)</p></td><td char="." align="char"><p>240 (30.89)</p></td><td char="." align="char"><p>346 (32.22)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left" /><td align="left"><p>Eczema</p></td><td char="." align="char"><p>56 (18.86)</p></td><td char="." align="char"><p>93 (11.97)</p></td><td char="." align="char"><p>149 (13.87)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left" /><td align="left"><p>Urticaria</p></td><td char="." align="char"><p>88 (29.63)</p></td><td char="." align="char"><p>232 (29.86)</p></td><td char="." align="char"><p>320 (29.80)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>CCD markers</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>294 (98.99)</p></td><td char="." align="char"><p>772 (99.36)</p></td><td char="." align="char"><p>1066 (99.26)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.692</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>3 (1.01)</p></td><td char="." align="char"><p>5 (0.64)</p></td><td char="." align="char"><p>8 (0.74)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Artemisia</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>273 (91.92)</p></td><td char="." align="char"><p>701 (90.22)</p></td><td char="." align="char"><p>974 (90.69)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.736</p></td><td char="." align="char"><p>0.391</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>24 (8.08)</p></td><td char="." align="char"><p>76 (9.78)</p></td><td char="." align="char"><p>100 (9.31)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Penicillium, Aspergillus, Aspergillus, Aspergillus</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>290 (97.64)</p></td><td char="." align="char"><p>772 (99.36)</p></td><td char="." align="char"><p>1062 (98.88)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.024</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>7 (2.36)</p></td><td char="." align="char"><p>5 (0.64)</p></td><td char="." align="char"><p>12 (1.12)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Dog epidermis</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>287 (96.63)</p></td><td char="." align="char"><p>745 (95.88)</p></td><td char="." align="char"><p>1032 (96.09)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.323</p></td><td char="." align="char"><p>0.570</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>10 (3.37)</p></td><td char="." align="char"><p>32 (4.12)</p></td><td char="." align="char"><p>42 (3.91)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Peanut</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>292 (98.32)</p></td><td char="." align="char"><p>770 (99.10)</p></td><td char="." align="char"><p>1062 (98.88)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.329</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>5 (1.68)</p></td><td char="." align="char"><p>7 (0.90)</p></td><td char="." align="char"><p>12 (1.12)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Soy</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>292 (98.32)</p></td><td char="." align="char"><p>771 (99.23)</p></td><td char="." align="char"><p>1063 (98.98)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.188</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>5 (1.68)</p></td><td char="." align="char"><p>6 (0.77)</p></td><td char="." align="char"><p>11 (1.02)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Chicken protein</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>292 (98.32)</p></td><td char="." align="char"><p>752 (96.78)</p></td><td char="." align="char"><p>1044 (97.21)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>1.862</p></td><td char="." align="char"><p>0.172</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>5 (1.68)</p></td><td char="." align="char"><p>25 (3.22)</p></td><td char="." align="char"><p>30 (2.79)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Willow, poplar, elm</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>288 (96.97)</p></td><td char="." align="char"><p>756 (97.30)</p></td><td char="." align="char"><p>1044 (97.21)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.085</p></td><td char="." align="char"><p>0.771</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>9 (3.03)</p></td><td char="." align="char"><p>21 (2.70)</p></td><td char="." align="char"><p>30 (2.79)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Cat hair</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>271 (91.25)</p></td><td char="." align="char"><p>697 (89.70)</p></td><td char="." align="char"><p>968 (90.13)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.574</p></td><td char="." align="char"><p>0.449</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>26 (8.75)</p></td><td char="." align="char"><p>80 (10.30)</p></td><td char="." align="char"><p>106 (9.87)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Milk</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>297 (100.0)</p></td><td char="." align="char"><p>766 (98.58)</p></td><td char="." align="char"><p>1063 (98.98)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.041</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>0 (0.00)</p></td><td char="." align="char"><p>11 (1.42)</p></td><td char="." align="char"><p>11 (1.02)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Beef</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>297 (100.0)</p></td><td char="." align="char"><p>768 (98.84)</p></td><td char="." align="char"><p>1065 (99.16)</p></td><td char="." align="char"><p>0</p></td><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>0 (0.00)</p></td><td char="." align="char"><p>9 (1.16)</p></td><td char="." align="char"><p>9 (0.84)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Ordinary Pigweed</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>288 (96.97)</p></td><td char="." align="char"><p>753 (96.91)</p></td><td char="." align="char"><p>1041 (96.93)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.002</p></td><td char="." align="char"><p>0.960</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>9 (3.03)</p></td><td char="." align="char"><p>24 (3.09)</p></td><td char="." align="char"><p>33 (3.07)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Herb Grass</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>281 (94.61)</p></td><td char="." align="char"><p>755 (97.17)</p></td><td char="." align="char"><p>1036 (96.46)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>4.112</p></td><td char="." align="char"><p>0.043</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>16 (5.39)</p></td><td char="." align="char"><p>22 (2.83)</p></td><td char="." align="char"><p>38 (3.54)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>House Dust</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>283 (95.29)</p></td><td char="." align="char"><p>740 (95.24)</p></td><td char="." align="char"><p>1023 (95.25)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.001</p></td><td char="." align="char"><p>0.974</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>14 (4.71)</p></td><td char="." align="char"><p>37 (4.76)</p></td><td char="." align="char"><p>51 (4.75)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>House Dust Mite, Dust Mite</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>252 (84.85)</p></td><td char="." align="char"><p>720 (92.66)</p></td><td char="." align="char"><p>972 (90.50)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>15.270</p></td><td char="." align="char"><p>0.000</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>45 (15.15)</p></td><td char="." align="char"><p>57 (7.34)</p></td><td char="." align="char"><p>102 (9.50)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Shrimp</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>293 (98.65)</p></td><td char="." align="char"><p>772 (99.36)</p></td><td char="." align="char"><p>1065 (99.16)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.271</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>4 (1.35)</p></td><td char="." align="char"><p>5 (0.64)</p></td><td char="." align="char"><p>9 (0.84)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Crab</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>289 (97.31)</p></td><td char="." align="char"><p>758 (97.55)</p></td><td char="." align="char"><p>1047 (97.49)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.054</p></td><td char="." align="char"><p>0.816</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>8 (2.69)</p></td><td char="." align="char"><p>19 (2.45)</p></td><td char="." align="char"><p>27 (2.51)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Lamb</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>292 (98.32)</p></td><td char="." align="char"><p>758 (97.55)</p></td><td char="." align="char"><p>1050 (97.77)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>0.571</p></td><td char="." align="char"><p>0.450</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>5 (1.68)</p></td><td char="." align="char"><p>19 (2.45)</p></td><td char="." align="char"><p>24 (2.23)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Cockroach</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>290 (97.64)</p></td><td char="." align="char"><p>767 (98.71)</p></td><td char="." align="char"><p>1057 (98.42)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.272</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>7 (2.36)</p></td><td char="." align="char"><p>10 (1.29)</p></td><td char="." align="char"><p>17 (1.58)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Cod, Lobster, Scallop</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>292 (98.32)</p></td><td char="." align="char"><p>769 (98.97)</p></td><td char="." align="char"><p>1061 (98.79)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.364</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>5 (1.68)</p></td><td char="." align="char"><p>8 (1.03)</p></td><td char="." align="char"><p>13 (1.21)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr></tbody></table> </ephtml> </p> <p>CCD, Cross-Reactive Carbohydrate Determinants.</p> <hd id="AN0180905578-11">Age-related variations in allergen sensitivity</hd> <p>We compared allergen sensitivity across different age groups and observed statistically significant differences (<emph>p</emph> < 0.05). In the age groups under 18, 18–40, 40–60, and ≥ 60 years, the allergen positivity rates were 56.3%, 32%, 26.6%, and 17.6%, respectively (Fig. 1). The results from Table 3 reveal significant differences in allergen sensitivity among different age groups. Firstly, regarding the number of allergens, individuals with two or more allergens exhibit significant differences in distribution across different age brackets (χ<sups>2</sups> = 46.186, <emph>p</emph> < 0.001). Additionally, concerning the total number of allergies, there are significant differences in the distribution of negative reactions across different age groups (χ<sups>2</sups> = 27.407, <emph>p</emph> < 0.001). In terms of diagnosis, the distribution of allergic dermatitis also shows significant differences across different age groups (χ<sups>2</sups> = 25.438, <emph>p</emph> = 0.003). Regarding specific allergens, the sensitivity distribution of Artemisia (χ<sups>2</sups> = 13.318, <emph>p</emph> = 0.004), dog epithelium (Fisher's Exact Test, <emph>p</emph> < 0.001), chicken protein (Fisher's Exact Test, <emph>p</emph> = 0.001), cat hair (χ<sups>2</sups> = 49.883, <emph>p</emph> < 0.000), milk (Fisher's Exact Test, <emph>p</emph> = 0.002), house dust (χ<sups>2</sups> = 19.439, <emph>p</emph> < 0.000), house dust mite (χ<sups>2</sups> = 21.031, <emph>p</emph> < 0.000), and lamb (Fisher's Exact Test, <emph>p</emph> = 0.008) exhibit significant differences in sensitivity distribution across different age groups. These results suggest that age may be an important factor influencing individual sensitivity to specific allergens.</p> <p>Graph: Fig. 1 The overall positivity rate of allergens across different age groups.</p> <p>Table 3 Distribution and comparative analysis of allergen sensitivity across different age groups.</p> <p> <ephtml> <table frame="hsides" rules="groups"><thead><tr><th align="left"><p>Variable</p></th><th align="left"><p>Variable Level</p></th><th align="left"><p>1 < 18 years old</p></th><th align="left"><p>2 18–40 years old</p></th><th align="left"><p>3 40–60 years old</p></th><th align="left"><p>4 ≥ 60 years old</p></th><th align="left"><p>Row Total</p></th><th align="left"><p>Total Missing</p></th><th align="left"><p>Test Method</p></th><th align="left"><p>Statistic (χ<sup>2</sup>)</p></th><th align="left"><p><italic>P</italic>-value</p></th></tr></thead><tbody><tr><td align="left"><p>Number of allergens</p></td><td align="left"><p>A Negative</p></td><td char="." align="char"><p>21 (43.75)</p></td><td char="." align="char"><p>444 (67.99)</p></td><td char="." align="char"><p>182 (73.39)</p></td><td char="." align="char"><p>103 (82.40)</p></td><td char="." align="char"><p>750 (69.83)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-Square</p></td><td align="left"><p>46.186</p></td><td char="." align="char"><p>0.000</p></td></tr><tr><td align="left" /><td align="left"><p>B 1 kind</p></td><td char="." align="char"><p>8 (16.67)</p></td><td char="." align="char"><p>92 (14.09)</p></td><td char="." align="char"><p>43 (17.34)</p></td><td char="." align="char"><p>16 (12.80)</p></td><td char="." align="char"><p>159 (14.80)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left" /><td align="left"><p>C 2 or more</p></td><td char="." align="char"><p>19 (39.58)</p></td><td char="." align="char"><p>117 (17.92)</p></td><td char="." align="char"><p>23 (9.27)</p></td><td char="." align="char"><p>6 (4.80)</p></td><td char="." align="char"><p>165 (15.36)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Allergy (total)</p></td><td align="left"><p>A Negative</p></td><td char="." align="char"><p>21 (43.75)</p></td><td char="." align="char"><p>444 (67.99)</p></td><td char="." align="char"><p>182 (73.39)</p></td><td char="." align="char"><p>103 (82.40)</p></td><td char="." align="char"><p>750 (69.83)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-Square</p></td><td align="left"><p>27.407</p></td><td char="." align="char"><p>0.000</p></td></tr><tr><td align="left" /><td align="left"><p>B Positive</p></td><td char="." align="char"><p>27 (56.25)</p></td><td char="." align="char"><p>209 (32.01)</p></td><td char="." align="char"><p>66 (26.61)</p></td><td char="." align="char"><p>22 (17.60)</p></td><td char="." align="char"><p>324 (30.17)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Diagnosis</p></td><td align="left"><p>Allergic dermatitis</p></td><td char="." align="char"><p>3 (6.25)</p></td><td char="." align="char"><p>164 (25.11)</p></td><td char="." align="char"><p>59 (23.79)</p></td><td char="." align="char"><p>33 (26.40)</p></td><td char="." align="char"><p>259 (24.12)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-Square</p></td><td align="left"><p>25.438</p></td><td char="." align="char"><p>0.003</p></td></tr><tr><td align="left" /><td align="left"><p>Other</p></td><td char="." align="char"><p>20 (41.67)</p></td><td char="." align="char"><p>214 (32.77)</p></td><td char="." align="char"><p>80 (32.26)</p></td><td char="." align="char"><p>32 (25.60)</p></td><td char="." align="char"><p>346 (32.22)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left" /><td align="left"><p>Eczema</p></td><td char="." align="char"><p>8 (16.67)</p></td><td char="." align="char"><p>78 (11.94)</p></td><td char="." align="char"><p>32 (12.90)</p></td><td char="." align="char"><p>31 (24.80)</p></td><td char="." align="char"><p>149 (13.87)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left" /><td align="left"><p>Urticaria</p></td><td char="." align="char"><p>17 (35.42)</p></td><td char="." align="char"><p>197 (30.17)</p></td><td char="." align="char"><p>77 (31.05)</p></td><td char="." align="char"><p>29 (23.20)</p></td><td char="." align="char"><p>320 (29.80)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>CCD Markers</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>48 (100.0)</p></td><td char="." align="char"><p>648 (99.23)</p></td><td char="." align="char"><p>245 (98.79)</p></td><td char="." align="char"><p>125 (100.0)</p></td><td char="." align="char"><p>1066 (99.26)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.761</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>0 (0.00)</p></td><td char="." align="char"><p>5 (0.77)</p></td><td char="." align="char"><p>3 (1.21)</p></td><td char="." align="char"><p>0 (0.00)</p></td><td char="." align="char"><p>8 (0.74)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Artemisia</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>38 (79.17)</p></td><td char="." align="char"><p>589 (90.20)</p></td><td char="." align="char"><p>226 (91.13)</p></td><td char="." align="char"><p>121 (96.80)</p></td><td char="." align="char"><p>974 (90.69)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-Square</p></td><td align="left"><p>13.318</p></td><td char="." align="char"><p>0.004</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>10 (20.83)</p></td><td char="." align="char"><p>64 (9.80)</p></td><td char="." align="char"><p>22 (8.87)</p></td><td char="." align="char"><p>4 (3.20)</p></td><td char="." align="char"><p>100 (9.31)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Penicillium, Aspergillus, Aspergillus, Aspergillus</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>46 (95.83)</p></td><td char="." align="char"><p>645 (98.77)</p></td><td char="." align="char"><p>246 (99.19)</p></td><td char="." align="char"><p>125 (100.0)</p></td><td char="." align="char"><p>1062 (98.88)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.154</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>2 (4.17)</p></td><td char="." align="char"><p>8 (1.23)</p></td><td char="." align="char"><p>2 (0.81)</p></td><td char="." align="char"><p>0 (0.00)</p></td><td char="." align="char"><p>12 (1.12)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Dog epithelium</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>40 (83.33)</p></td><td char="." align="char"><p>623 (95.41)</p></td><td char="." align="char"><p>245 (98.79)</p></td><td char="." align="char"><p>124 (99.20)</p></td><td char="." align="char"><p>1032 (96.09)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.000</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>8 (16.67)</p></td><td char="." align="char"><p>30 (4.59)</p></td><td char="." align="char"><p>3 (1.21)</p></td><td char="." align="char"><p>1 (0.80)</p></td><td char="." align="char"><p>42 (3.91)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Peanut</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>48 (100.0)</p></td><td char="." align="char"><p>647 (99.08)</p></td><td char="." align="char"><p>243 (97.98)</p></td><td char="." align="char"><p>124 (99.20)</p></td><td char="." align="char"><p>1062 (98.88)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.536</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>0 (0.00)</p></td><td char="." align="char"><p>6 (0.92)</p></td><td char="." align="char"><p>5 (2.02)</p></td><td char="." align="char"><p>1 (0.80)</p></td><td char="." align="char"><p>12 (1.12)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Soy</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>48 (100.0)</p></td><td char="." align="char"><p>646 (98.93)</p></td><td char="." align="char"><p>247 (99.60)</p></td><td char="." align="char"><p>122 (97.60)</p></td><td char="." align="char"><p>1063 (98.98)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.272</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>0 (0.00)</p></td><td char="." align="char"><p>7 (1.07)</p></td><td char="." align="char"><p>1 (0.40)</p></td><td char="." align="char"><p>3 (2.40)</p></td><td char="." align="char"><p>11 (1.02)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Egg white</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>42 (87.50)</p></td><td char="." align="char"><p>642 (98.32)</p></td><td char="." align="char"><p>241 (97.18)</p></td><td char="." align="char"><p>119 (95.20)</p></td><td char="." align="char"><p>1044 (97.21)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.001</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>6 (12.50)</p></td><td char="." align="char"><p>11 (1.68)</p></td><td char="." align="char"><p>7 (2.82)</p></td><td char="." align="char"><p>6 (4.80)</p></td><td char="." align="char"><p>30 (2.79)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Willow, Poplar, Elm</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>43 (89.58)</p></td><td char="." align="char"><p>635 (97.24)</p></td><td char="." align="char"><p>243 (97.98)</p></td><td char="." align="char"><p>123 (98.40)</p></td><td char="." align="char"><p>1044 (97.21)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.707</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>5 (10.42)</p></td><td char="." align="char"><p>18 (2.76)</p></td><td char="." align="char"><p>5 (2.02)</p></td><td char="." align="char"><p>2 (1.60)</p></td><td char="." align="char"><p>30 (2.79)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Cat hair</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>34 (70.83)</p></td><td char="." align="char"><p>570 (87.29)</p></td><td char="." align="char"><p>240 (96.77)</p></td><td char="." align="char"><p>124 (99.20)</p></td><td char="." align="char"><p>968 (90.13)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>49.883</p></td><td char="." align="char"><p>0.000</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>14 (29.17)</p></td><td char="." align="char"><p>83 (12.71)</p></td><td char="." align="char"><p>8 (3.23)</p></td><td char="." align="char"><p>1 (0.80)</p></td><td char="." align="char"><p>106 (9.87)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Milk</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>44 (91.67)</p></td><td char="." align="char"><p>649 (99.39)</p></td><td char="." align="char"><p>246 (99.19)</p></td><td char="." align="char"><p>124 (99.20)</p></td><td char="." align="char"><p>1063 (98.98)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.002</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>4 (8.33)</p></td><td char="." align="char"><p>4 (0.61)</p></td><td char="." align="char"><p>2 (0.81)</p></td><td char="." align="char"><p>1 (0.80)</p></td><td char="." align="char"><p>11 (1.02)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Beef</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>45 (93.75)</p></td><td char="." align="char"><p>649 (99.39)</p></td><td char="." align="char"><p>247 (99.60)</p></td><td char="." align="char"><p>124 (99.20)</p></td><td char="." align="char"><p>1065 (99.16)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.013</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>3 (6.25)</p></td><td char="." align="char"><p>4 (0.61)</p></td><td char="." align="char"><p>1 (0.40)</p></td><td char="." align="char"><p>1 (0.80)</p></td><td char="." align="char"><p>9 (0.84)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Common Pigweed</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>46 (95.83)</p></td><td char="." align="char"><p>631 (96.63)</p></td><td char="." align="char"><p>241 (97.18)</p></td><td char="." align="char"><p>123 (98.40)</p></td><td char="." align="char"><p>1041 (96.93)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.707</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>2 (4.17)</p></td><td char="." align="char"><p>22 (3.37)</p></td><td char="." align="char"><p>7 (2.82)</p></td><td char="." align="char"><p>2 (1.60)</p></td><td char="." align="char"><p>33 (3.07)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Goosefoot</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>45 (93.75)</p></td><td char="." align="char"><p>635 (97.24)</p></td><td char="." align="char"><p>233 (93.95)</p></td><td char="." align="char"><p>123 (98.40)</p></td><td char="." align="char"><p>1036 (96.46)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.040</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>3 (6.25)</p></td><td char="." align="char"><p>18 (2.76)</p></td><td char="." align="char"><p>15 (6.05)</p></td><td char="." align="char"><p>2 (1.60)</p></td><td char="." align="char"><p>38 (3.54)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>House Dust</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>42 (87.50)</p></td><td char="." align="char"><p>613 (93.87)</p></td><td char="." align="char"><p>243 (97.98)</p></td><td char="." align="char"><p>125 (100.0)</p></td><td char="." align="char"><p>1023 (95.25)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>19.439</p></td><td char="." align="char"><p>0.000</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>6 (12.50)</p></td><td char="." align="char"><p>40 (6.13)</p></td><td char="." align="char"><p>5 (2.02)</p></td><td char="." align="char"><p>0 (0.00)</p></td><td char="." align="char"><p>51 (4.75)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>House Dust Mites, Dust Mites</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>37 (77.08)</p></td><td char="." align="char"><p>581 (88.97)</p></td><td char="." align="char"><p>233 (93.95)</p></td><td char="." align="char"><p>121 (96.80)</p></td><td char="." align="char"><p>972 (90.50)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Chi-square</p></td><td align="left"><p>21.031</p></td><td char="." align="char"><p>0.000</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>11 (22.92)</p></td><td char="." align="char"><p>72 (11.03)</p></td><td char="." align="char"><p>15 (6.05)</p></td><td char="." align="char"><p>4 (3.20)</p></td><td char="." align="char"><p>102 (9.50)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Shrimp</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>46 (95.83)</p></td><td char="." align="char"><p>650 (99.54)</p></td><td char="." align="char"><p>245 (98.79)</p></td><td char="." align="char"><p>124 (99.20)</p></td><td char="." align="char"><p>1065 (99.16)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.058</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>2 (4.17)</p></td><td char="." align="char"><p>3 (0.46)</p></td><td char="." align="char"><p>3 (1.21)</p></td><td char="." align="char"><p>1 (0.80)</p></td><td char="." align="char"><p>9 (0.84)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Crab</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>46 (95.83)</p></td><td char="." align="char"><p>636 (97.40)</p></td><td char="." align="char"><p>243 (97.98)</p></td><td char="." align="char"><p>122 (97.60)</p></td><td char="." align="char"><p>1047 (97.49)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.758</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>2 (4.17)</p></td><td char="." align="char"><p>17 (2.60)</p></td><td char="." align="char"><p>5 (2.02)</p></td><td char="." align="char"><p>3 (2.40)</p></td><td char="." align="char"><p>27 (2.51)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Lamb</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>44 (91.67)</p></td><td char="." align="char"><p>636 (97.40)</p></td><td char="." align="char"><p>247 (99.60)</p></td><td char="." align="char"><p>123 (98.40)</p></td><td char="." align="char"><p>1050 (97.77)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.008</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>4 (8.33)</p></td><td char="." align="char"><p>17 (2.60)</p></td><td char="." align="char"><p>1 (0.40)</p></td><td char="." align="char"><p>2 (1.60)</p></td><td char="." align="char"><p>24 (2.23)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Cockroach</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>47 (97.92)</p></td><td char="." align="char"><p>646 (98.93)</p></td><td char="." align="char"><p>240 (96.77)</p></td><td char="." align="char"><p>124 (99.20)</p></td><td char="." align="char"><p>1057 (98.42)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.099</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>1 (2.08)</p></td><td char="." align="char"><p>7 (1.07)</p></td><td char="." align="char"><p>8 (3.23)</p></td><td char="." align="char"><p>1 (0.80)</p></td><td char="." align="char"><p>17 (1.58)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr><tr><td align="left"><p>Cod, Lobster, Scallop</p></td><td align="left"><p>1 Negative</p></td><td char="." align="char"><p>47 (97.92)</p></td><td char="." align="char"><p>646 (98.93)</p></td><td char="." align="char"><p>245 (98.79)</p></td><td char="." align="char"><p>123 (98.40)</p></td><td char="." align="char"><p>1061 (98.79)</p></td><td char="." align="char"><p>0</p></td><td align="left"><p>Fisher's Exact Test</p></td><td align="left"><p>-</p></td><td char="." align="char"><p>0.663</p></td></tr><tr><td align="left" /><td align="left"><p>2 Positive</p></td><td char="." align="char"><p>1 (2.08)</p></td><td char="." align="char"><p>7 (1.07)</p></td><td char="." align="char"><p>3 (1.21)</p></td><td char="." align="char"><p>2 (1.60)</p></td><td char="." align="char"><p>13 (1.21)</p></td><td align="left" /><td align="left" /><td align="left" /><td align="left" /></tr></tbody></table> </ephtml> </p> <p>CCD, Cross-Reactive Carbohydrate Determinants.</p> <hd id="AN0180905578-12">Analysis of concurrent positive reactions to two allergens</hd> <p>We further analyzed data of concurrent positive reactions to two allergens and calculated their percentages. The top 10 combinations with the highest proportions were as follows: dog epithelium and cat hair at 11.1%, common pigweed and Artemisia at 9.9%, Artemisia and cat hair at 9.0%, dust mite and cat hair at 8.6%, house dust and cat hair at 8.6%, willow, poplar, elm, and Artemisia at 7.7%, Artemisia and dust mite at 7.1%, Artemisia and herb grass at 6.5%, Artemisia and house dust at 6.5%, and dust mite and crab at 4.6% (Fig. 2). Additionally, we presented the results using a clustering diagram (Fig. 3).</p> <p>Graph: Fig. 2 Cross-reactivity heatmap of antigen (allergen) testing: The numbers in the figure represent the percentage of simultaneous positivity for two antigens, with darker colors indicating higher percentages. The antigens represented by each letter are listed in the table on the right.</p> <p>Graph: Fig. 3 Network clustering diagram of cross-reactive antigens: The size of each circle in the figure represents the corresponding antigen's positivity proportion, with larger circles indicating higher positivity rates. The lines connecting two circles represent the proportion of simultaneous positivity for both antigens; thicker lines indicate higher simultaneous positivity rates. Clustering of circles indicates a tendency for certain antigens to co-occur positively. The specific antigens represented by each letter are detailed in the table on the right.</p> <p>The logistic regression analysis demonstrated that age was a significant risk factor in allergen positivity across multiple categories. Specifically, individuals under 18 years old had significantly higher odds of testing positive for several allergens. For IgE positivity, those under 18 years had a notably increased risk (Wald Chi-Square = 19.58, <emph>p</emph> < 0.001), while other age groups showed no significant associations. Regarding common allergens, positivity for Artemisia absinthium was significantly associated with being under 18 years of age (<emph>p</emph> = 0.001), with no such relationship observed in older age groups. Similarly, for dust mites, both male sex and age under 18 were significant factors, with males showing increased odds (<emph>p</emph> < 0.001) and children under 18 years also demonstrating a higher risk of sensitization (<emph>p</emph> < 0.001). For Penicillium nodosum and related fungi, males were more likely to test positive (<emph>p</emph> = 0.019), though age did not emerge as a significant factor. Likewise, positivity for egg white allergen was significantly linked to both children under 18 years (<emph>p</emph> = 0.001) and individuals aged 18–40 years (<emph>p</emph> = 0.001). Interestingly, for cat hair allergen, being younger than 18 years (<emph>p</emph> < 0.001) or between 18 and 40 years (<emph>p</emph> = 0.005) was associated with higher positivity rates. However, male sex was not a significant factor for these allergens. Conversely, factors like sex and age did not significantly affect positivity for allergens like crab, cod, or other shellfish, as reflected by non-significant p-values (Table 4). In summary, age under 18 years appeared to be the most consistent predictor of allergen positivity across various categories, with male sex showing specific associations for certain allergens such as dust mites and fungal allergens.</p> <p>Table 4 Multifactorial logostic regression to analyze factors of allergen positivity.</p> <p> <ephtml> <table frame="hsides" rules="groups"><thead><tr><th align="left"><p>Item</p></th><th align="left"><p>Variable</p></th><th align="left"><p>Risk factors</p></th><th align="left"><p>SE</p></th><th align="left"><p>Wald Chi-Square</p></th><th align="left"><p><italic>P</italic> value</p></th></tr></thead><tbody><tr><td align="left"><p>IgE positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.075</p></td><td align="left"><p>0.929</p></td><td align="left"><p>0.335</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.23</p></td><td align="left"><p>19.58</p></td><td align="left"><p>0</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.119</p></td><td align="left"><p>0.031</p></td><td align="left"><p>0.859</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.144</p></td><td align="left"><p>2.904</p></td><td align="left"><p>0.088</p></td></tr><tr><td align="left"><p>CCD positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.368</p></td><td align="left"><p>0.528</p></td><td align="left"><p>0.467</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>186.9</p></td><td align="left"><p>0.001</p></td><td align="left"><p>0.978</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>71.76</p></td><td align="left"><p>0.005</p></td><td align="left"><p>0.945</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>71.76</p></td><td align="left"><p>0.006</p></td><td align="left"><p>0.94</p></td></tr><tr><td align="left"><p>Positive for Artemisia absinthium</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.124</p></td><td align="left"><p>0.449</p></td><td align="left"><p>0.503</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.302</p></td><td align="left"><p>10.7</p></td><td align="left"><p>0.001</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.193</p></td><td align="left"><p>0.235</p></td><td align="left"><p>0.628</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.231</p></td><td align="left"><p>0.002</p></td><td align="left"><p>0.965</p></td></tr><tr><td align="left"><p>Penicillium nodosum, Mycosphaerella, Aspergillus fumigatus, Streptomyces coelicolor positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.296</p></td><td align="left"><p>5.531</p></td><td align="left"><p>0.019</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>121.4</p></td><td align="left"><p>0.001</p></td><td align="left"><p>0.972</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>121.4</p></td><td align="left"><p>0.001</p></td><td align="left"><p>0.98</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>121.4</p></td><td align="left"><p>0</p></td><td align="left"><p>0.983</p></td></tr><tr><td align="left"><p>Dog epithelium positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.188</p></td><td align="left"><p>0.176</p></td><td align="left"><p>0.675</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.413</p></td><td align="left"><p>20.22</p></td><td align="left"><p>0</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.337</p></td><td align="left"><p>1.574</p></td><td align="left"><p>0.21</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.514</p></td><td align="left"><p>3.344</p></td><td align="left"><p>0.067</p></td></tr><tr><td align="left"><p>Peanut positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.297</p></td><td align="left"><p>1.179</p></td><td align="left"><p>0.278</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>244.1</p></td><td align="left"><p>0.001</p></td><td align="left"><p>0.973</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>81.37</p></td><td align="left"><p>0.001</p></td><td align="left"><p>0.975</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>81.37</p></td><td align="left"><p>0.002</p></td><td align="left"><p>0.967</p></td></tr><tr><td align="left"><p>Soybean positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.309</p></td><td align="left"><p>1.401</p></td><td align="left"><p>0.237</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>252.3</p></td><td align="left"><p>0.001</p></td><td align="left"><p>0.974</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>84.11</p></td><td align="left"><p>0.001</p></td><td align="left"><p>0.973</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>84.11</p></td><td align="left"><p>0</p></td><td align="left"><p>0.983</p></td></tr><tr><td align="left"><p>Egg white positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.251</p></td><td align="left"><p>2.577</p></td><td align="left"><p>0.108</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.367</p></td><td align="left"><p>10.64</p></td><td align="left"><p>0.001</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.292</p></td><td align="left"><p>11.29</p></td><td align="left"><p>0.001</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.334</p></td><td align="left"><p>1.611</p></td><td align="left"><p>0.204</p></td></tr><tr><td align="left"><p>Willow, Poplar, Elm Positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.204</p></td><td align="left"><p>0.104</p></td><td align="left"><p>0.748</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.417</p></td><td align="left"><p>9.404</p></td><td align="left"><p>0.002</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.302</p></td><td align="left"><p>0.172</p></td><td align="left"><p>0.679</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.405</p></td><td align="left"><p>1.239</p></td><td align="left"><p>0.266</p></td></tr><tr><td align="left"><p>Cat hair positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.122</p></td><td align="left"><p>0.134</p></td><td align="left"><p>0.714</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.359</p></td><td align="left"><p>27.23</p></td><td align="left"><p>0</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.292</p></td><td align="left"><p>7.999</p></td><td align="left"><p>0.005</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.378</p></td><td align="left"><p>2.91</p></td><td align="left"><p>0.088</p></td></tr><tr><td align="left"><p>Milk positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>82.91</p></td><td align="left"><p>0.005</p></td><td align="left"><p>0.943</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.52</p></td><td align="left"><p>13.46</p></td><td align="left"><p>0</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.504</p></td><td align="left"><p>3.281</p></td><td align="left"><p>0.07</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.618</p></td><td align="left"><p>0.887</p></td><td align="left"><p>0.346</p></td></tr><tr><td align="left"><p>Beef positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>95.15</p></td><td align="left"><p>0.004</p></td><td align="left"><p>0.95</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.59</p></td><td align="left"><p>9.752</p></td><td align="left"><p>0.002</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.539</p></td><td align="left"><p>1.492</p></td><td align="left"><p>0.222</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.817</p></td><td align="left"><p>1.574</p></td><td align="left"><p>0.21</p></td></tr><tr><td align="left"><p>Common ragweed positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.199</p></td><td align="left"><p>0.003</p></td><td align="left"><p>0.953</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.581</p></td><td align="left"><p>0.479</p></td><td align="left"><p>0.489</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.317</p></td><td align="left"><p>0.331</p></td><td align="left"><p>0.565</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.387</p></td><td align="left"><p>0</p></td><td align="left"><p>0.998</p></td></tr><tr><td align="left"><p>Humulus japonicus positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.169</p></td><td align="left"><p>4.103</p></td><td align="left"><p>0.043</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.491</p></td><td align="left"><p>1.376</p></td><td align="left"><p>0.241</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.302</p></td><td align="left"><p>0.591</p></td><td align="left"><p>0.442</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.313</p></td><td align="left"><p>3.206</p></td><td align="left"><p>0.073</p></td></tr><tr><td align="left"><p>House dust positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.163</p></td><td align="left"><p>0.076</p></td><td align="left"><p>0.783</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>114.1</p></td><td align="left"><p>0.002</p></td><td align="left"><p>0.969</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>114.1</p></td><td align="left"><p>0.001</p></td><td align="left"><p>0.974</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>114.1</p></td><td align="left"><p>0</p></td><td align="left"><p>0.982</p></td></tr><tr><td align="left"><p>House dust mite, dust mite positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.108</p></td><td align="left"><p>17.46</p></td><td align="left"><p>0</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.301</p></td><td align="left"><p>15.2</p></td><td align="left"><p>0</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.194</p></td><td align="left"><p>3.102</p></td><td align="left"><p>0.078</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.256</p></td><td align="left"><p>2.045</p></td><td align="left"><p>0.153</p></td></tr><tr><td align="left"><p>Shrimp positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.34</p></td><td align="left"><p>1.01</p></td><td align="left"><p>0.315</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.632</p></td><td align="left"><p>4.225</p></td><td align="left"><p>0.04</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.555</p></td><td align="left"><p>2.611</p></td><td align="left"><p>0.106</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.554</p></td><td align="left"><p>0.008</p></td><td align="left"><p>0.929</p></td></tr><tr><td align="left"><p>Crab positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.215</p></td><td align="left"><p>0.059</p></td><td align="left"><p>0.809</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.576</p></td><td align="left"><p>0.614</p></td><td align="left"><p>0.433</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.319</p></td><td align="left"><p>0.008</p></td><td align="left"><p>0.929</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.416</p></td><td align="left"><p>0.502</p></td><td align="left"><p>0.479</p></td></tr><tr><td align="left"><p>Lamb positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.256</p></td><td align="left"><p>0.509</p></td><td align="left"><p>0.476</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.502</p></td><td align="left"><p>9.115</p></td><td align="left"><p>0.003</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.383</p></td><td align="left"><p>0.49</p></td><td align="left"><p>0.484</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.786</p></td><td align="left"><p>4.179</p></td><td align="left"><p>0.041</p></td></tr><tr><td align="left"><p>Cockroach positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.251</p></td><td align="left"><p>1.511</p></td><td align="left"><p>0.219</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.81</p></td><td align="left"><p>0.135</p></td><td align="left"><p>0.713</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.467</p></td><td align="left"><p>0.508</p></td><td align="left"><p>0.476</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.457</p></td><td align="left"><p>2.802</p></td><td align="left"><p>0.094</p></td></tr><tr><td align="left"><p>Cod, lobster, scallop positive</p></td><td align="left"><p>Sex</p></td><td align="left"><p>Male</p></td><td char="." align="char"><p>0.289</p></td><td align="left"><p>0.648</p></td><td align="left"><p>0.421</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>< 18 years old</p></td><td char="." align="char"><p>0.798</p></td><td align="left"><p>0.219</p></td><td align="left"><p>0.64</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>18–40 years old</p></td><td char="." align="char"><p>0.447</p></td><td align="left"><p>0.361</p></td><td align="left"><p>0.548</p></td></tr><tr><td align="left" /><td align="left"><p>Age</p></td><td align="left"><p>40–60 years old</p></td><td char="." align="char"><p>0.543</p></td><td align="left"><p>0.094</p></td><td align="left"><p>0.759</p></td></tr></tbody></table> </ephtml> </p> <hd id="AN0180905578-13">Discussion</hd> <p>Our research findings reveal significant disparities in allergen sensitivity across different genders and age groups. Females exhibited higher sensitivity rates compared to males, with notable differences in specific allergens such as cat hair and house dust mites. Age-wise, children and adolescents showed the highest positivity rates, indicating heightened susceptibility at a younger age. Our comprehensive analysis of allergen detection results unveils nuanced insights into the complexities of allergen sensitivity, shedding light on significant variations across different demographic groups. By integrating our findings with existing knowledge, we can better understand the intricate interplay between gender, age, and allergen exposure in shaping individual allergic responses.</p> <p>Gender Disparities in Allergen Sensitivity Our study underscores notable gender disparities in allergen sensitivity, with females exhibiting a substantially higher prevalence of sensitivity compared to males. This observation aligns with previous research indicating that females are more prone to allergic conditions[<reflink idref="bib18" id="ref15">18</reflink>]–[<reflink idref="bib20" id="ref16">20</reflink>]. Several factors may contribute to this gender-based variation. Firstly, hormonal influences, particularly estrogen, may modulate immune responses and predispose females to heightened allergic reactions[<reflink idref="bib20" id="ref17">20</reflink>]–[<reflink idref="bib23" id="ref18">23</reflink>]. Additionally, differences in skin barrier function and exposure to environmental allergens could contribute to increased sensitivity among females[<reflink idref="bib24" id="ref19">24</reflink>],[<reflink idref="bib25" id="ref20">25</reflink>]. Our findings further elucidate specific allergens where gender differences are particularly pronounced, including Penicillium, Aspergillus, milk, herbaceous plants, and house dust mites. These gender-specific patterns underscore the importance of tailoring allergy management strategies to account for gender-related factors and highlight the need for further research into the underlying mechanisms driving these differences.</p> <p>Age-Related Variations in Allergen Sensitivity Our analysis reveals significant age-related variations in allergen sensitivity, with distinct patterns emerging across different age groups. Younger individuals, particularly those under 18 years old, demonstrate a higher prevalence of allergen sensitivity compared to older age groups. This finding is consistent with the notion that allergic conditions often manifest early in life and may gradually decline with age[<reflink idref="bib26" id="ref21">26</reflink>]–[<reflink idref="bib28" id="ref22">28</reflink>]. Interestingly, our study identifies specific allergens that exhibit differential sensitivity distribution across age groups, including Artemisia, dog epithelium, cat hair, and others. These age-specific patterns underscore the dynamic nature of allergic responses and suggest that age-related factors play a crucial role in shaping individual susceptibility to allergens[<reflink idref="bib29" id="ref23">29</reflink>]. Clinically, our findings emphasize the importance of considering age-related factors in allergy diagnosis and management, as tailored approaches may be necessary to effectively address allergen sensitivities across different life stages.</p> <p>Analysis of Concurrent Positive Reactions to Two Allergens Furthermore, our analysis of concurrent positive reactions to multiple allergens provides valuable insights into the complex nature of allergic responses. We identified several combinations of allergens that elicited concurrent positive reactions, suggesting potential cross-reactivity or synergistic effects. Notably, the top combinations included dog epithelium and cat hair, common pigweed and Artemisia, and Artemisia and cat hair, among others. The simultaneous positive reactions to these allergens suggest potential cross-reactivity or co-sensitization among them. This implies that individuals allergic to one allergen may exhibit similar allergic reactions to another allergen, thereby adding complexity to allergic symptoms[<reflink idref="bib30" id="ref24">30</reflink>]. These findings underscore the need for comprehensive allergen testing to identify coexisting sensitivities and inform personalized allergy management strategies. By elucidating these complex interactions, our study contributes to a deeper understanding of the underlying mechanisms driving allergic responses and provides valuable insights into the development of targeted interventions to alleviate allergic symptoms effectively.</p> <p>Although our study has yielded important findings, there are several limitations that should be considered. Firstly, our research is based on sample data from a single region, which may introduce regional variations and limit the generalizability of our results. Secondly, our study employs a cross-sectional design, which precludes establishing causality and only allows for observing correlations. Additionally, the relatively small sample size in our study may restrict the analysis of certain subgroups, such as finer age groupings. Lastly, we only considered some common allergens in our study and may have overlooked other potential allergens. Therefore, when interpreting our results and formulating relevant policies, it is important to carefully consider these limitations and further refine and validate our findings in future research.</p> <p>In conclusion, our study offers valuable contributions to the field of allergy research by elucidating the intricate relationships between gender, age, and allergen sensitivity. By integrating our findings with existing knowledge, we enhance our understanding of allergen profiles and pave the way for more effective approaches to allergy diagnosis, management, and treatment. However, further research is warranted to explore the underlying mechanisms driving gender and age-related differences in allergen sensitivity and to develop personalized strategies to address individual allergic responses comprehensively.</p> <hd id="AN0180905578-14">Acknowledgements</hd> <p>We are grateful to all staff professionals and participants.</p> <hd id="AN0180905578-15">Author contributions</hd> <p>BW and DZ contributed to the conception and design of the study; ZH J and DZ performed the experiments, collected and analyzed data; BW and ZH J wrote the manuscript; FL revised the manuscript. All authors reviewed and approved the final version of the manuscript.</p> <hd id="AN0180905578-16">Data availability</hd> <p>The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.</p> <hd id="AN0180905578-17">Declarations</hd> <p></p> <hd id="AN0180905578-18">Competing interests</hd> <p>The authors declare no competing interests.</p> <hd id="AN0180905578-19">Ethics approval and consent to participate</hd> <p>The current study was conducted in accordance with the Helsinki Declaration of the World Medical Association and approved by the Ethics Committee of Beijing Chao-yang Hospital, Capital Medical University. 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  Group: Ti
  Data: Analysis of allergen positivity rates in relation to gender, age, and cross-reactivity patterns
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  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ben+Wang%22">Ben Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Di+Zhang%22">Di Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Zhihui+Jiang%22">Zhihui Jiang</searchLink><br /><searchLink fieldCode="AR" term="%22Fang+Liu%22">Fang Liu</searchLink>
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  Label: Source
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  Data: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
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  Label: Publisher Information
  Group: PubInfo
  Data: Nature Portfolio, 2024.
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  Label: Publication Year
  Group: Date
  Data: 2024
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  Data: LCC:Medicine<br />LCC:Science
– Name: Subject
  Label: Subject Terms
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  Data: <searchLink fieldCode="DE" term="%22Allergens%22">Allergens</searchLink><br /><searchLink fieldCode="DE" term="%22Sensitivity%22">Sensitivity</searchLink><br /><searchLink fieldCode="DE" term="%22Gender+disparities%22">Gender disparities</searchLink><br /><searchLink fieldCode="DE" term="%22Age-related+variations%22">Age-related variations</searchLink><br /><searchLink fieldCode="DE" term="%22Concurrent+reactions%22">Concurrent reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Science%22">Science</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Abstract Objective: This study aims to gain a deeper understanding of the patterns of allergen detection positivity rates among different age and gender groups, and to explore cross-reactivity patterns among allergens. Methods: We conducted a retrospective analysis of patients who underwent allergen testing at our hospital. The sample for this study included all patients who underwent allergen testing. We utilized immune blotting to detect specific IgE antibodies to 20 allergens in patient sera. Results: The study results showed a higher proportion of female samples (72.35%) compared to male samples (27.65%). Among all participants, the age distribution was primarily concentrated in the 25–35 age group, accounting for 37.43% of the total sample, followed by the 45 years and older age group, accounting for 27.00%. This indicates that allergic symptoms may occur not only in children and adolescents but also at any time after adulthood. We further observed significant influences of factors such as gender and age on individual sensitivity to specific allergens. For example, compared to males, females were found to be more sensitive to certain allergens such as cat hair, dust mites, and dog epithelium. Similarly, we also found variations in sensitivity to specific allergens among different age groups. Conclusion: Close monitoring of allergen distribution in populations facilitates active engagement of allergic individuals in self-management, while gender and age may be important factors influencing individual sensitivity to specific allergens. These findings provide valuable insights for understanding the pathogenesis of allergic diseases and designing more effective prevention and treatment strategies.
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  Data: 2045-2322
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  Data: https://doaj.org/toc/2045-2322
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  Data: 10.1038/s41598-024-78909-y
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      – Type: doi
        Value: 10.1038/s41598-024-78909-y
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      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 1
    Subjects:
      – SubjectFull: Allergens
        Type: general
      – SubjectFull: Sensitivity
        Type: general
      – SubjectFull: Gender disparities
        Type: general
      – SubjectFull: Age-related variations
        Type: general
      – SubjectFull: Concurrent reactions
        Type: general
      – SubjectFull: Medicine
        Type: general
      – SubjectFull: Science
        Type: general
    Titles:
      – TitleFull: Analysis of allergen positivity rates in relation to gender, age, and cross-reactivity patterns
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            NameFull: Ben Wang
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            NameFull: Di Zhang
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            NameFull: Zhihui Jiang
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            NameFull: Fang Liu
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            – D: 01
              M: 11
              Type: published
              Y: 2024
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