Academic Journal
Cutaneous Involvement in Diseases with Plasma Cell Differentiation: Diagnostic Approach
| Title: | Cutaneous Involvement in Diseases with Plasma Cell Differentiation: Diagnostic Approach |
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| Authors: | Magda Zanelli, Andrea Palicelli, Francesca Sanguedolce, Maurizio Zizzo, Alessandra Filosa, Linda Ricci, Camilla Cresta, Giovanni Martino, Alessandra Bisagni, Eleonora Zanetti, Francesco di Donato, Beatrice Melli, Alessandra Soriano, Luca Cimino, Alberto Cavazza, Lisa Francesca Vivian, Stefano Ascani |
| Source: | Current Oncology, Vol 29, Iss 5, Pp 3026-3043 (2022) |
| Publisher Information: | MDPI AG, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | plasma cell neoplasms, multiple myeloma, primary cutaneous marginal zone lymphoma, amyloidoma, plasmablastic lymphoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Neoplasms with plasma cell differentiation may occasionally involve the skin. Cutaneous lesions may represent the first sign of an underlying systemic plasma cell malignancy, such as multiple myeloma, or the skin itself may be the primary site of occurrence of a hematological tumor with plasma cell differentiation. Starting from examples encountered in our daily practice, we discussed the diagnostic approach pathologists and clinicians should use when faced with cutaneous lesions with plasma cell differentiation. Cases of primary cutaneous marginal zone lymphoma, localized primary amyloidosis/amyloidoma, and cutaneous manifestations (secondary either to multiple myeloma or to plasmablastic lymphoma) are discussed, focusing on the importance of the adequate patient’s work-up and precise clinicopathological correlation to get to the correct diagnosis and appropriate treatment. The pertinent literature has been reviewed, and the clinical presentation, pathological findings, main differential diagnoses, treatment, and outcome of neoplasms with plasma cell differentiation involving the skin are discussed. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1718-7729 1198-0052 |
| Relation: | https://www.mdpi.com/1718-7729/29/5/246; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729 |
| DOI: | 10.3390/curroncol29050246 |
| Access URL: | https://doaj.org/article/e25884af2bdb4b319070412ca71bcf49 |
| Accession Number: | edsdoj.25884af2bdb4b319070412ca71bcf49 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17187729 11980052 |
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| DOI: | 10.3390/curroncol29050246 |
| Published in: | Current Oncology |
| Language: | English |