Academic Journal
Opposite effects of low and high frequency deep brain stimulation of lateral hypothalamus on arousal and temperature in a monkey pilot study
| Title: | Opposite effects of low and high frequency deep brain stimulation of lateral hypothalamus on arousal and temperature in a monkey pilot study |
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| Authors: | Aurélie Davin, Stéphan Chabardès, Napoléon Torres-Martinez, Brigitte Piallat |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Parkinson’s disease, Lateral hypothalamic area, Deep brain stimulation, Excessive daytime sleepiness, Medicine, Science |
| More Details: | Abstract Deep brain stimulation is a well-established treatment for improving motor symptoms in Parkinson’s disease. However, persistent non-motor symptoms, such as excessive daytime sleepiness, remain a significant challenge and necessitate further investigation. In this study, we conducted repeated measurements of daytime sleepiness using a modified multiple sleep latency test in a healthy monkey (macaca fascicularis), which was later rendered parkinsonian through MPTP administration. Deep brain stimulation targeting the lateral hypothalamic area revealed frequency-dependent modulation of both sleepiness level and core body temperature. High-frequency stimulation (80 Hz) increased sleepiness in the healthy state, while low-frequency stimulation (20 Hz) promoted wakefulness in the parkinsonian state. These findings suggest a promising therapeutic approach for addressing sleep/wake disturbances, not only in Parkinson’s disease but also in other severe sleep disorders. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-79508-7 |
| Access URL: | https://doaj.org/article/2584ed4378664a578ccfd342d0f58089 |
| Accession Number: | edsdoj.2584ed4378664a578ccfd342d0f58089 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-79508-7 |
| Published in: | Scientific Reports |
| Language: | English |