Prediction of future insulin‐deficiency in glutamic acid decarboxylase autoantibody enzyme‐linked immunosorbent assay‐positive patients with slowly‐progressive type 1 diabetes
| Title: | Prediction of future insulin‐deficiency in glutamic acid decarboxylase autoantibody enzyme‐linked immunosorbent assay‐positive patients with slowly‐progressive type 1 diabetes |
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| Authors: | Eiji Kawasaki, Takuya Awata, Hiroshi Ikegami, Akihisa Imagawa, Yoichi Oikawa, Haruhiko Osawa, Takeshi Katsuki, Norio Kanatsuna, Ryoichi Kawamura, Junji Kozawa, Noriko Kodani, Tetsuro Kobayashi, Akira Shimada, Masayuki Shimoda, Kazuma Takahashi, Daisuke Chujo, Tetsuro Tsujimoto, Kyoichiro Tsuchiya, Aiko Terakawa, Jungo Terasaki, Kan Nagasawa, Shinsuke Noso, Tomoyasu Fukui, Ichiro Horie, Kazuki Yasuda, Hisafumi Yasuda, Hidekatsu Yanai, Toshiaki Hanafusa, Hiroshi Kajio, the Japanese Type 1 Diabetes Database Study (TIDE‐J) |
| Source: | Journal of Diabetes Investigation, Vol 15, Iss 7, Pp 835-842 (2024) |
| Publisher Information: | Wiley, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | Glutamic acid decarboxylase, Prediction, Slowly‐progressive type 1 diabetes, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Abstract Aims/Introduction This study aimed to identify risk factors that contribute to the progression of slowly‐progressive type 1 diabetes by evaluating the positive predictive value (PPV) of factors associated with the progression to an insulin‐dependent state. Materials and Methods We selected 60 slowly‐progressive type 1 diabetes patients who tested positive for glutamic acid decarboxylase autoantibodies (GADA) at diagnosis from the Japanese Type 1 Diabetes Database Study. GADA levels in these patients were concurrently measured using both radioimmunoassay (RIA) and enzyme‐linked immunosorbent assay (ELISA) techniques. Results Compared with the non‐progressor group (fasting C‐peptide [F‐CPR] levels maintained ≥0.6 ng/mL), the progressor group showed a younger age at diagnosis, lower body mass index (BMI), lower F‐CPR levels and a higher prevalence of insulinoma‐associated antigen‐2 autoantibodies (IA‐2A). The PPV of RIA‐GADA increased from 56.3 to 70.0% in the high titer group (≥10 U/mL), and further increased to 76.9, 84.2, 81.0 and 75.0% when combined with specific thresholds for age at diagnosis |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2040-1124 2040-1116 97621838 |
| Relation: | https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124 |
| DOI: | 10.1111/jdi.14178 |
| Access URL: | https://doaj.org/article/2548a80a84c24af5abc976218388891e |
| Accession Number: | edsdoj.2548a80a84c24af5abc976218388891e |
| Database: | Directory of Open Access Journals |
| ISSN: | 20401124 20401116 97621838 |
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| DOI: | 10.1111/jdi.14178 |
| Published in: | Journal of Diabetes Investigation |
| Language: | English |