Academic Journal
Effect of atractylenolide III on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium
| Title: | Effect of atractylenolide III on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium |
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| Authors: | Na Yeon Kim, Myoung Ok Kim, Sangsu Shin, Woo-Sung Kwon, Bomi Kim, Joon Yeop Lee, Sang In Lee |
| Source: | Journal of Animal Science and Biotechnology, Vol 15, Iss 1, Pp 1-12 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Animal culture LCC:Veterinary medicine |
| Subject Terms: | Atractylenolide III, Epithelial–mesenchymal transition, IPEC-J2 cells, Snail, TGF-beta signaling, Zearalenone, Animal culture, SF1-1100, Veterinary medicine, SF600-1100 |
| More Details: | Abstract Background The intestinal epithelium performs essential physiological functions, such as nutrient absorption, and acts as a barrier to prevent the entry of harmful substances. Mycotoxins are prevalent contaminants found in animal feed that exert harmful effects on the health of livestock. Zearalenone (ZEA) is produced by the Fusarium genus and induces gastrointestinal dysfunction and disrupts the health and immune system of animals. Here, we evaluated the molecular mechanisms that regulate the effects of ZEA on the porcine intestinal epithelium. Results Treatment of IPEC-J2 cells with ZEA decreased the expression of E-cadherin and increased the expression of Snai1 and Vimentin, which induced Snail1-mediated epithelial-to-mesenchymal transition (EMT). In addition, ZEA induces Snail-mediated EMT through the activation of TGF-β signaling. The treatment of IPEC-J2 cells with atractylenolide III, which were exposed to ZEA, alleviated EMT. Conclusions Our findings provide insights into the molecular mechanisms of ZEA toxicity in porcine intestinal epithelial cells and ways to mitigate it. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2049-1891 |
| Relation: | https://doaj.org/toc/2049-1891 |
| DOI: | 10.1186/s40104-024-01038-z |
| Access URL: | https://doaj.org/article/24ef1aa81bbb4dc89ddbb557ddb39f81 |
| Accession Number: | edsdoj.24ef1aa81bbb4dc89ddbb557ddb39f81 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20491891 |
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| DOI: | 10.1186/s40104-024-01038-z |
| Published in: | Journal of Animal Science and Biotechnology |
| Language: | English |