Bibliographic Details
| Title: |
EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia |
| Authors: |
Johan Courjon, Patrick Munro, Yvonne Benito, Orane Visvikis, Coralie Bouchiat, Laurent Boyer, Anne Doye, Hubert Lepidi, Eric Ghigo, Jean-Philippe Lavigne, François Vandenesch, Emmanuel Lemichez |
| Source: |
Toxins, Vol 7, Iss 10, Pp 4131-4142 (2015) |
| Publisher Information: |
MDPI AG, 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
bacteremia, virulence factor, toxins, methicillin-resistant Staphylococcus aureus, Medicine |
| More Details: |
It is crucial to define risk factors that contribute to host invasion by Staphylococcus aureus. Here, we demonstrate that the chromosomally encoded EDIN-B isoform from S. aureus contributes to the onset of bacteremia during the course of pneumonia. Deletion of edinB in a European lineage community-acquired methicillin resistant S. aureus (CA-MRSA) strain (ST80-MRSA-IV) dramatically decreased the frequency and magnitude of bacteremia in mice suffering from pneumonia. This deletion had no effect on the bacterial burden in both blood circulation and lung tissues. Re-expression of wild-type EDIN-B, unlike the catalytically inactive mutant EDIN-R185E, restored the invasive characteristics of ST80-MRSA-IV. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2072-6651 |
| Relation: |
http://www.mdpi.com/2072-6651/7/10/4131; https://doaj.org/toc/2072-6651 |
| DOI: |
10.3390/toxins7104131 |
| Access URL: |
https://doaj.org/article/e24b1a3d505d42daaf3c50a45184f157 |
| Accession Number: |
edsdoj.24b1a3d505d42daaf3c50a45184f157 |
| Database: |
Directory of Open Access Journals |
