Academic Journal
Longitudinal association of peripheral blood DNA methylation with liver fat content: distinguishing between predictors and biomarkers
| Title: | Longitudinal association of peripheral blood DNA methylation with liver fat content: distinguishing between predictors and biomarkers |
|---|---|
| Authors: | Hailuan Zeng, Wenran Li, Mingfeng Xia, Jieyu Ge, Hui Ma, Lingyan Chen, Baishen Pan, Huandong Lin, Sijia Wang, Xin Gao |
| Source: | Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-13 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Nutritional diseases. Deficiency diseases |
| Subject Terms: | Liver fat content, DNA methylation, Cross-lagged panel analysis, Longitudinal study, Nutritional diseases. Deficiency diseases, RC620-627 |
| More Details: | Abstract Background Alterations in DNA methylation (DNAm) have been observed in patients with fatty liver, but whether they are cause or consequence remains unknown. The study aimed to investigate longitudinal association of epigenome-wide DNAm with liver fat content (LFC) in Chinese participants, and explore their temporal relationships. Methods Data were obtained from 2 waves over a four-year time period of the Shanghai Changfeng Study (discovery, n = 407 and replication, n = 126). LFC and peripheral blood DNAm were repeatedly measured using quantitative hepatic ultrasonography and the 850 K Illumina EPIC BeadChip, respectively. Longitudinal and cross-sectional epigenome-wide association studies (EWASs) were conducted with linear mixed model and linear regression model, respectively. Meta-analysis was performed using METAL. Cross-lagged panel analysis (CLPA) was carried out to infer temporal relationships between the significant CpGs and LFC. Results Longitudinal EWAS identified cg11024682 (SREBF1), cg06500161 (ABCG1), cg16740586 (ABCG1), cg15659943 (ABCA1) and cg00163198 (SNX19) significantly associated with LFC with P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1476-511X 24684317 |
| Relation: | https://doaj.org/toc/1476-511X |
| DOI: | 10.1186/s12944-024-02304-9 |
| Access URL: | https://doaj.org/article/246843172265432ea31c7e1abe31c36c |
| Accession Number: | edsdoj.246843172265432ea31c7e1abe31c36c |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 1476511X 24684317 |
|---|---|
| DOI: | 10.1186/s12944-024-02304-9 |
| Published in: | Lipids in Health and Disease |
| Language: | English |