Allogeneic islet transplantation with monitoring of islet‐specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report
| Title: | Allogeneic islet transplantation with monitoring of islet‐specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report |
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| Authors: | Daisuke Chujo, Toshiaki Kurokawa, Akitsu Kawabe, Nobuyuki Takahashi, Fuyuki Inagaki, Koya Shinohara, Shotaro Hagiwara, Yoshihiro Edamoto, Norio Ohmagari, Fumihiko Hinoshita, Tsuyoshi Tajima, Hiroshi Kajio, Hiroshi Ohtsu, Nobuyuki Takemura, Shinichi Matsumoto, Masayuki Shimoda |
| Source: | Journal of Diabetes Investigation, Vol 13, Iss 4, Pp 741-745 (2022) |
| Publisher Information: | Wiley, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | Autoimmune response, Type 1 diabetes mellitus, Islet transplantation, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Abstract Here, we report a case of allogeneic islet transplantation in Japan. A 48‐year‐old man received intraportal islet transplantation (5,945 islet equivalent/kg), and stabilization of blood glucose levels and suppression of hypoglycemia were achieved. In the present case, we used our original assessment method to detect the responses of the recipient’s T cells to islet autoantigens over time to monitor cellular autoimmunity. Other markers could not predict graft dysfunction in advance, but our method detected the activation of islet antigen‐specific CD8+ T‐cell responses before the deterioration of pancreatic β‐cell function, indicating the possibility of the non‐invasive detection of pancreatic β‐cell damage due to recurrent autoimmunity. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2040-1124 2040-1116 |
| Relation: | https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124 |
| DOI: | 10.1111/jdi.13715 |
| Access URL: | https://doaj.org/article/24301e867dee4c72a63e191cf0743177 |
| Accession Number: | edsdoj.24301e867dee4c72a63e191cf0743177 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20401124 20401116 |
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| DOI: | 10.1111/jdi.13715 |
| Published in: | Journal of Diabetes Investigation |
| Language: | English |