Bibliographic Details
| Title: |
Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion |
| Authors: |
Zenan Wang, Binghao Li, Shan Li, Wenlong Lin, Zhan Wang, Shengdong Wang, Weida Chen, Wei Shi, Tao Chen, Hao Zhou, Eloy Yinwang, Wenkan Zhang, Haochen Mou, Xupeng Chai, Jiahao Zhang, Zhimin Lu, Zhaoming Ye |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Chemo-resistance and immune evasion are major challenges in osteosarcoma treatment. Here the authors show that doxorubicin promotes IL-18 secretion by tumor associated macrophages inducing LAT2-dependent CD47 upregulation in osteosarcoma cells, suggesting LAT2 inhibition as a therapeutic option in combination with doxorubicin. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-34064-4 |
| Access URL: |
https://doaj.org/article/242307c6508642058c15bbbd18691354 |
| Accession Number: |
edsdoj.242307c6508642058c15bbbd18691354 |
| Database: |
Directory of Open Access Journals |
