Bibliographic Details
| Title: |
Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways |
| Authors: |
Yuting Jiang, Lihong Xu, Yifan Cao, Fantao Meng, Shujun Jiang, Mengyu Yang, Ziteng Zheng, Yi Zhang, Lu Yang, Meiqin Wang, Guizhi Sun, Jing Liu, Chen Li, Minghu Cui |
| Source: |
Brain Research Bulletin, Vol 212, Iss , Pp 110952- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
Acute restraint stress, Anxiety, Medial prefrontal cortex, Interleukin-19, Interleukin 20α receptor, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Anxiety is a prevalent mental illness known for its high incidence, comorbidity, and tendency to recur, posing significant societal and individual burdens. Studies have highlighted Interleukin-19 (IL-19) as having potential relevance in neuropsychiatric disorders. Our previous research revealed that IL-19 overexpression in colonies exacerbated anxiety-related behaviors induced by dextran sodium sulfate/stress. However, the precise role and molecular mechanisms of IL-19 in anxiety regulation remain uncertain. In this study, we initiated an acute restraint stress (ARS)-induced anxious mouse model and identified heightened expression of IL-19 and IL-20Rα in the medial prefrontal cortex (mPFC) of ARS mice. Notably, IL-19 and IL-20Rα were predominantly present in the excitatory pyramidal neurons of the mPFC under both basal and ARS conditions. Utilizing the adeno-associated virus (AAV) strategy, we demonstrated that IL-19 overexpression in the mPFC induced anxiety-related behaviors and elevated stress susceptibility. Additionally, we observed decreased protein levels of brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95) in the mPFC of IL-19 overexpression mice, accompanied by reduced phosphorylation of in the p38, JNK, and Erk signaling pathways. These findings emphasize the role of IL-19 in modulating anxiety-related behaviors within the mPFC and suggest its potential as a pathological gene and therapeutic target for anxiety. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1873-2747 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0361923024000856; https://doaj.org/toc/1873-2747 |
| DOI: |
10.1016/j.brainresbull.2024.110952 |
| Access URL: |
https://doaj.org/article/241c134c28ed4321b5463a6facccd3a9 |
| Accession Number: |
edsdoj.241c134c28ed4321b5463a6facccd3a9 |
| Database: |
Directory of Open Access Journals |
