Bibliographic Details
| Title: |
Mesenchymal stem cell–derived extracellular vesicles in joint diseases: Therapeutic effects and underlying mechanisms |
| Authors: |
Jinhui Wu, Jiangyi Wu, Zheng Liu, Yunquan Gong, Daibo Feng, Wei Xiang, Shunzheng Fang, Ran Chen, Yaran Wu, Shu Huang, Yizhao Zhou, Ningning Liu, Hao Xu, Siru Zhou, Baorong Liu, Zhenhong Ni |
| Source: |
Journal of Orthopaedic Translation, Vol 48, Iss , Pp 53-69 (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the musculoskeletal system |
| Subject Terms: |
Extracellular vesicles, Mesenchymal stem cells, Osteoarthritis, Osteonecrosis of the femoral head, Rheumatoid arthritis, Tendon and ligament injuries, Diseases of the musculoskeletal system, RC925-935 |
| More Details: |
Joint diseases greatly impact the daily lives and occupational functioning of patients globally. However, conventional treatments for joint diseases have several limitations, such as unsatisfatory efficacy and side effects, necessitating the exploration of more efficacious therapeutic strategies. Mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have demonstrated high therapeutic efficacyin tissue repair and regeneration, with low immunogenicity and tumorigenicity. Recent studies have reported that EVs-based therapy has considerable therapeutic effects against joint diseases, including osteoarthritis, tendon and ligament injuries, femoral head osteonecrosis, and rheumatoid arthritis. Herein, we review the therapeutic potential of various types of MSC-EVs in the aforementioned joint diseases, summarise the mechanisms underlying specific biological effects of MSC-EVs, and discuss future prospects for basic research on MSC-EV-based therapeutic modalities and their clinical translation. In general, this review provides an in-depth understanding of the therapeutic effects of MSC-EVs in joint diseases, as well as the underlying mechanisms, which may be beneficial to the clinical translation of MSC-EV-based treatment.The translational potential of this article: MSC-EV-based cell-free therapy can effectively promote regeneration and tissue repair. When used to treat joint diseases, MSC-EVs have demonstrated desirable therapeutic effects in preclinical research. This review may supplement further research on MSC-EV-based treatment of joint diseases and its clinical translation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2214-031X |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2214031X24000731; https://doaj.org/toc/2214-031X |
| DOI: |
10.1016/j.jot.2024.07.005 |
| Access URL: |
https://doaj.org/article/c239a3464d9d4ec78dc777ce99cf12ed |
| Accession Number: |
edsdoj.239a3464d9d4ec78dc777ce99cf12ed |
| Database: |
Directory of Open Access Journals |
