Innate immune sensors for detecting nucleic acids during infection
| Title: | Innate immune sensors for detecting nucleic acids during infection |
|---|---|
| Authors: | Ghoreshi Zohreh-alsadat, Nakhaee Mohsen, Samie Mohammad, Zak Mohsen Sharif, Arefinia Nasir |
| Source: | Journal of Laboratory Medicine, Vol 46, Iss 3, Pp 155-164 (2022) |
| Publisher Information: | De Gruyter, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medical technology |
| Subject Terms: | cytoplasm innate immune system, endoplasmic innate immune system, innate immune response, innate immune sensors, nuclear innate immune system, Medical technology, R855-855.5 |
| More Details: | Innate immune receptors detect nucleic acids, such as viruses, and initiate an immune response by secreting interferon (IFN) and regulating IFN-stimulated genes (ISG). in autoimmune conditions, expression of ISGs funded, show the activation of nucleic acid sensory pathways. However, the nucleus-localized innate sensors are recently found to detect pathogenic nucleic acids for initiating innate response, demonstrating a complicated crosstalk with cytoplasmic sensors and signaling molecules to form an elaborate tiered innate signaling network between nucleus and cytoplasm. to sustain immune hemostasis, these innate immune sensors develop different strategies for discriminating between self or non-self-nucleic acid. We reviewed all the sensors involved in the innate immune system in the present study. A better understanding of these sensors can lead to new treatments for infections, cancer, and autoimmune and inflammatory disorders. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2567-9430 2567-9449 |
| Relation: | https://doaj.org/toc/2567-9430; https://doaj.org/toc/2567-9449 |
| DOI: | 10.1515/labmed-2021-0173 |
| Access URL: | https://doaj.org/article/237330a3dd294fb58e05879e0c48a91c |
| Accession Number: | edsdoj.237330a3dd294fb58e05879e0c48a91c |
| Database: | Directory of Open Access Journals |
| ISSN: | 25679430 25679449 |
|---|---|
| DOI: | 10.1515/labmed-2021-0173 |
| Published in: | Journal of Laboratory Medicine |
| Language: | English |