Prognostic Value of Systemic Inflammation, Nutritional Status and Sarcopenia in Patients With Amyotrophic Lateral Sclerosis
| Title: | Prognostic Value of Systemic Inflammation, Nutritional Status and Sarcopenia in Patients With Amyotrophic Lateral Sclerosis |
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| Authors: | Yahui Zhu, Ying Zhang, Mao Li, Jiongming Bai, Hongfen Wang, Xinyuan Pang, Rongrong Du, Jiao Wang, Xusheng Huang |
| Source: | Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 6, Pp 2743-2755 (2024) |
| Publisher Information: | Wiley, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the musculoskeletal system LCC:Human anatomy |
| Subject Terms: | amyotrophic lateral sclerosis, inflammation, nutrition, sarcopenia index, survival, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695 |
| More Details: | ABSTRACT Background Nutritional status, systemic inflammatory responses and muscle mass are associated with the prognosis of patients with amyotrophic lateral sclerosis (ALS). However, the optimal biomarker for predicting prognosis remains unclear. This study aimed to identify the optimal indicators of survival among the nutrition‐based, inflammation‐based and muscle mass–related markers for ALS patients. Methods We enrolled ALS patients from January 2014 to December 2019. Experienced neurologists followed up with the participants until January 2022. This study included a total of 17 nutritional, systemic inflammatory or muscle mass–related indicators. Maximally selected rank statistics determined the cut‐off points for these indicators. Kaplan–Meier estimation was used to assess survival. Uni‐ and multivariate Cox proportional hazards models were used to determine the effects of indicators on survival. Finally, time‐dependent receiver operating characteristic (time‐ROC) curves and the C‐index were calculated to evaluate the predictive efficacy of different indicators. Results A total of 506 patients with ALS were enrolled in this study, including 288 males (56.9%) and 218 females (43.1%), with a mean age of 54.2 ± 10.5 years. Among these ALS patients, 334 cases (68.0%) either died or underwent tracheotomy. In univariate Cox proportional hazards regression, 11 indicators were significantly associated with ALS survival (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2190-6009 2190-5991 |
| Relation: | https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009 |
| DOI: | 10.1002/jcsm.13618 |
| Access URL: | https://doaj.org/article/d236ee4f27f64c608473579bc9fd87b6 |
| Accession Number: | edsdoj.236ee4f27f64c608473579bc9fd87b6 |
| Database: | Directory of Open Access Journals |
| ISSN: | 21906009 21905991 |
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| DOI: | 10.1002/jcsm.13618 |
| Published in: | Journal of Cachexia, Sarcopenia and Muscle |
| Language: | English |