Bibliographic Details
| Title: |
Local Epidemiology of Nosocomial Staphylococcus aureus Infection in a Nigerian University Teaching Hospital |
| Authors: |
Adeniran Adeyanju, Frieder Schaumburg, Adedeji Onayade, Akinyele Akinyoola, Taofeeq Adeyemi, Osaretin Ugbo, Robin Köck, Yemisi Amusa, Oladejo Lawal, Temilade Adeyanju, Nkem Torimiro, David Akinpelu, Deboye Kolawole, Christian Kohler, Karsten Becker |
| Source: |
Antibiotics, Vol 11, Iss 10, p 1372 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
Staphylococcus aureus, MRSA, nosocomial infection, surgical patients, skin and soft-tissue infections, Panton-Valentine leukocidin, Therapeutics. Pharmacology, RM1-950 |
| More Details: |
Population-based studies of Staphylococcus aureus contribute to understanding the epidemiology of S. aureus infection. We enrolled surgical inpatients admitted to an African tertiary-care hospital in order to prospectively analyze the nosocomial impact of S. aureus. Data collection included an active sampling of the anterior nares and infectious foci within 48 h after admission and subsequently when clinically indicated. All S. aureus isolates were spa and agr genotyped. Possession of Panton-Valentine leukocidin (PVL) and other toxin genes was determined. We analyzed antibiotic susceptibility profiles by VITEK 2 systems and verified methicillin-resistant S. aureus (MRSA) by mecA/C PCR. Among 325 patients, 15.4% carried methicillin-susceptible S. aureus (MSSA) at admission, while 3.7% carried MRSA. The incidence densities of nosocomial infections due to MSSA and MRSA were 35.4 and 6.2 infections per 10,000 patient-days, respectively. Among all 47 nosocomial infections, skin and soft-tissue (40.4%) and bones or joints’ (25.5%) infections predominated. Six (12.7%) infection-related S. aureus isolates harbored PVL genes including two (4.2%) MRSA: overall, seventeen (36.2%) isolates carried pyrogenic toxin superantigens or other toxin genes. This study illustrates the considerable nosocomial impact of S. aureus in a Nigerian University hospital. Furthermore, they indicate a need for effective approaches to curtail nosocomial acquisition of multidrug-resistant S. aureus. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2079-6382 |
| Relation: |
https://www.mdpi.com/2079-6382/11/10/1372; https://doaj.org/toc/2079-6382 |
| DOI: |
10.3390/antibiotics11101372 |
| Access URL: |
https://doaj.org/article/c22f21b66a904cf3b14a18e015096c87 |
| Accession Number: |
edsdoj.22f21b66a904cf3b14a18e015096c87 |
| Database: |
Directory of Open Access Journals |
