Association of close-range contact patterns with SARS-CoV-2: a household transmission study
| Title: | Association of close-range contact patterns with SARS-CoV-2: a household transmission study |
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| Authors: | Jackie Kleynhans, Lorenzo Dall'Amico, Laetitia Gauvin, Michele Tizzoni, Lucia Maloma, Sibongile Walaza, Neil A Martinson, Anne von Gottberg, Nicole Wolter, Mvuyo Makhasi, Cheryl Cohen, Ciro Cattuto, Stefano Tempia, SA-S-HTS Group |
| Source: | eLife, Vol 12 (2023) |
| Publisher Information: | eLife Sciences Publications Ltd, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Science LCC:Biology (General) |
| Subject Terms: | SARS-CoV-2, transmission, household, contacts, Medicine, Science, Biology (General), QH301-705.5 |
| More Details: | Background: Households are an important location for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, especially during periods when travel and work was restricted to essential services. We aimed to assess the association of close-range contact patterns with SARS-CoV-2 transmission. Methods: We deployed proximity sensors for two weeks to measure face-to-face interactions between household members after SARS-CoV-2 was identified in the household, in South Africa, 2020–2021. We calculated the duration, frequency, and average duration of close-range proximity events with SARS-CoV-2 index cases. We assessed the association of contact parameters with SARS-CoV-2 transmission using mixed effects logistic regression accounting for index and household member characteristics. Results: We included 340 individuals (88 SARS-CoV-2 index cases and 252 household members). On multivariable analysis, factors associated with SARS-CoV-2 acquisition were index cases with minimum Ct value 35, and female contacts (aOR 2.5 95% CI 1.3–5.0). No contact parameters were associated with acquisition (aOR 1.0–1.1) for any of the duration, frequency, cumulative time in contact, or average duration parameters. Conclusions: We did not find an association between close-range proximity events and SARS-CoV-2 household transmission. Our findings may be due to study limitations, that droplet-mediated transmission during close-proximity contacts plays a smaller role than airborne transmission of SARS-CoV-2 in the household, or due to high contact rates in households. Funding: Wellcome Trust (Grant number 221003/Z/20/Z) in collaboration with the Foreign, Commonwealth, and Development Office, United Kingdom. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2050-084X |
| Relation: | https://elifesciences.org/articles/84753; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.84753 |
| Access URL: | https://doaj.org/article/22bb89166649467fbddc8f8458730bb7 |
| Accession Number: | edsdoj.22bb89166649467fbddc8f8458730bb7 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2050084X |
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| DOI: | 10.7554/eLife.84753 |
| Published in: | eLife |
| Language: | English |