Bibliographic Details
| Title: |
Dynamics of Virus-Receptor Interactions in Virus Binding, Signaling, and Endocytosis |
| Authors: |
Steeve Boulant, Megan Stanifer, Pierre-Yves Lozach |
| Source: |
Viruses, Vol 7, Iss 6, Pp 2794-2815 (2015) |
| Publisher Information: |
MDPI AG, 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
binding, endocytosis, signalization, single particle tracking, uptake, virus receptor, Microbiology, QR1-502 |
| More Details: |
During viral infection the first challenge that viruses have to overcome is gaining access to the intracellular compartment. The infection process starts when the virus contacts the surface of the host cell. A complex series of events ensues, including diffusion at the host cell membrane surface, binding to receptors, signaling, internalization, and delivery of the genetic information. The focus of this review is on the very initial steps of virus entry, from receptor binding to particle uptake into the host cell. We will discuss how viruses find their receptor, move to sub-membranous regions permissive for entry, and how they hijack the receptor-mediated signaling pathway to promote their internalization. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4915 |
| Relation: |
http://www.mdpi.com/1999-4915/7/6/2747; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v7062747 |
| Access URL: |
https://doaj.org/article/227744e5459a4b64ae2e0f89f9952c1d |
| Accession Number: |
edsdoj.227744e5459a4b64ae2e0f89f9952c1d |
| Database: |
Directory of Open Access Journals |
