| Title: |
Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer |
| Authors: |
Lorenza Landi, Federica D’Incà, Alain Gelibter, Rita Chiari, Francesco Grossi, Angelo Delmonte, Antonio Passaro, Diego Signorelli, Francesco Gelsomino, Domenico Galetta, Diana Giannarelli, Hector Soto Parra, Gabriele Minuti, Marcello Tiseo, Maria Rita Migliorino, Francesco Cognetti, Luca Toschi, Paolo Bidoli, Francovito Piantedosi, Luana Calabro’, Federico Cappuzzo |
| Source: |
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019) |
| Publisher Information: |
BMJ Publishing Group, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Bone metastases, Nivolumab, Immunotherapy, PD-L1, Non-small-cell lung cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Background Bone metastases (BoM) are a negative prognostic factor in non-small-cell lung cancer (NSCLC). Beyond its supportive role, bone is a hematopoietic organ actively regulating immune system. We hypothesized that BoM may influence sensitivity to immunotherapy. Methods Pretreated non-squamous (cohort A) and squamous (cohort B) NSCLCs included in the Italian Expanded Access Program were evaluated for nivolumab efficacy according to BoM. Results Cohort A accounted for 1588 patients with non-squamous NSCLC, including 626 (39%) with (BoM+) and 962 (61%) without BoM (BoM-). Cohort B accounted for 371 patients with squamous histology including 120 BoM+ (32%) and 251 (68%) BoM- cases. BoM+ had lower overall response rate (ORR; Cohort A: 12% versus 23%, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2051-1426 |
| Relation: |
http://link.springer.com/article/10.1186/s40425-019-0793-8; https://doaj.org/toc/2051-1426 |
| DOI: |
10.1186/s40425-019-0793-8 |
| Access URL: |
https://doaj.org/article/2272c4a411464ed7ab0c54c8cd9b40b4 |
| Accession Number: |
edsdoj.2272c4a411464ed7ab0c54c8cd9b40b4 |
| Database: |
Directory of Open Access Journals |
