Bibliographic Details
| Title: |
Esketamine combined with dexmedetomidine and lidocaine induced inbition of tracheal intubation response |
| Authors: |
DENG Dongxiang, WU Duozhi |
| Source: |
Xin yixue, Vol 55, Iss 5, Pp 335-341 (2024) |
| Publisher Information: |
Editorial Office of Journal of New Medicine, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
esketamine, opioid-free anesthesia, tracheal intubation, median effective dose, sequential method, Medicine |
| More Details: |
Objective To investigate the median effective dose （ED50） of esketamine for inhibiting tracheal intubation response during the induction of dexmedetomidine combined with lidocaine under opioid-free anesthesia （OFA）. Methods Adult patients aged 18-59 years with body mass index （BMI）50 and 95% confidence interval （CI） of esketamine for inhibiting tracheal intubation response during the induction of dexmedetomidine combined with lidocaine OFA were calculated. Results A total of 29 patients were included for statistical analysis. Tracheal intubation reaction was positive in 15 cases （positive group） and negative in 14 cases （negative group）. In the positive group， 3 cases had cough reaction during tracheal intubation. The ED50 of esketamine for inhibiting tracheal intubation response during the induction of dexmedetomidine combined with lidocaine OFA was 0.448 mg/kg， and the corresponding 95%CI was 0.421-0.476 mg/kg. Conclusion In the OFA of esketamine combined with dexmedetomidine and lidocaine， 0.448 mg/kg of esketamine results in 50% of the maximum response intensity for inhibiting tracheal intubation response. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
Chinese |
| ISSN: |
0253-9802 |
| Relation: |
https://www.xinyixue.cn/fileup/0253-9802/PDF/1718248194547-714411587.pdf; https://doaj.org/toc/0253-9802 |
| DOI: |
10.3969/j.issn.0253-9802.2024.05.003 |
| Access URL: |
https://doaj.org/article/223153f958a24de49f4aca4544c49bda |
| Accession Number: |
edsdoj.223153f958a24de49f4aca4544c49bda |
| Database: |
Directory of Open Access Journals |
