Bibliographic Details
| Title: |
Adaptive anti‐myocardial immune response following hospitalization for acute heart failure |
| Authors: |
Caroline Morbach, Niklas Beyersdorf, Thomas Kerkau, Gustavo Ramos, Floran Sahiti, Judith Albert, Roland Jahns, Georg Ertl, Christiane E. Angermann, Stefan Frantz, Ulrich Hofmann, Stefan Störk |
| Source: |
ESC Heart Failure, Vol 8, Iss 4, Pp 3348-3353 (2021) |
| Publisher Information: |
Wiley, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Adaptive immune response, Acute heart failure, Anti‐myocardial, Autoantibody, Inflammation, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Abstract Aims It has been hypothesized that cardiac decompensation accompanying acute heart failure (AHF) episodes generates a pro‐inflammatory environment boosting an adaptive immune response against myocardial antigens, thus contributing to progression of heart failure (HF) and poor prognosis. We assessed the prevalence of anti‐myocardial autoantibodies (AMyA) as biomarkers reflecting adaptive immune responses in patients admitted to the hospital for AHF, followed the change in AMyA titres for 6 months after discharge, and evaluated their prognostic utility. Methods and results AMyA were determined in n = 47 patients, median age 71 (quartiles 60; 80) years, 23 (49%) female, and 24 (51%) with HF with preserved ejection fraction, from blood collected at baseline (time point of hospitalization) and at 6 month follow‐up (visit F6). Patients were followed for 18 months (visit F18). The prevalence of AMyA increased from baseline (n = 21, 45%) to F6 (n = 36, 77%; P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-5822 |
| Relation: |
https://doaj.org/toc/2055-5822 |
| DOI: |
10.1002/ehf2.13376 |
| Access URL: |
https://doaj.org/article/21dd7adb792648419af734c9c8f88b2d |
| Accession Number: |
edsdoj.21dd7adb792648419af734c9c8f88b2d |
| Database: |
Directory of Open Access Journals |
