Cytokine Profile in Striated Muscle Laminopathies: New Promising Biomarkers for Disease Prediction

Bibliographic Details
Title: Cytokine Profile in Striated Muscle Laminopathies: New Promising Biomarkers for Disease Prediction
Authors: Cristina Cappelletti, Irene Tramacere, Paola Cavalcante, Elisa Schena, Luisa Politano, Nicola Carboni, Alessandra Gambineri, Adele D’Amico, Lucia Ruggiero, Giulia Ricci, Gabriele Siciliano, Giuseppe Boriani, Tiziana Enrica Mongini, Liliana Vercelli, Elena Biagini, Matteo Ziacchi, Maria Rosaria D’Apice, Giovanna Lattanzi, Renato Mantegazza, Lorenzo Maggi, Pia Bernasconi
Source: Cells, Vol 9, Iss 6, p 1532 (2020)
Publisher Information: MDPI AG, 2020.
Publication Year: 2020
Collection: LCC:Cytology
Subject Terms: cytokines, laminopathies, macrophages, muscle damage, skeletal muscle, Cytology, QH573-671
More Details: Laminopathies are a wide and heterogeneous group of rare human diseases caused by mutations of the LMNA gene or related nuclear envelope genes. The variety of clinical phenotypes and the wide spectrum of histopathological changes among patients carrying an identical mutation in the LMNA gene make the prognostic process rather difficult, and classical genetic screens appear to have limited predictive value for disease development. The aim of this study was to evaluate whether a comprehensive profile of circulating cytokines may be a useful tool to differentiate and stratify disease subgroups, support clinical follow-ups and contribute to new therapeutic approaches. Serum levels of 51 pro- and anti-inflammatory molecules, including cytokines, chemokines and growth factors, were quantified by a Luminex multiple immune-assay in 53 patients with muscular laminopathy (Musc-LMNA), 10 with non-muscular laminopathy, 22 with other muscular disorders and in 35 healthy controls. Interleukin-17 (IL-17), granulocyte colony-stimulating factor (G-CSF) and transforming growth factor beta (TGF-β2) levels significantly discriminated Musc-LMNA from controls; interleukin-1β (IL-1β), interleukin-4 (IL-4) and interleukin-8 (IL-8) were differentially expressed in Musc-LMNA patients compared to those with non-muscular laminopathies, whereas IL-17 was significantly higher in Musc-LMNA patients with muscular and cardiac involvement. These findings support the hypothesis of a key role of the immune system in Musc-LMNA and emphasize the potential use of cytokines as biomarkers for these disorders.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2073-4409
Relation: https://www.mdpi.com/2073-4409/9/6/1532; https://doaj.org/toc/2073-4409
DOI: 10.3390/cells9061532
Access URL: https://doaj.org/article/ae21da996c0c4d5f9ab438a12d84dbf7
Accession Number: edsdoj.21da996c0c4d5f9ab438a12d84dbf7
Database: Directory of Open Access Journals
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More Details
ISSN:20734409
DOI:10.3390/cells9061532
Published in:Cells
Language:English