Bibliographic Details
| Title: |
MiR-145 inhibits metastasis by targeting fascin actin-bundling protein 1 in nasopharyngeal carcinoma. |
| Authors: |
Ying-Qin Li, Qing-Mei He, Xian-Yue Ren, Xin-Ran Tang, Ya-Fei Xu, Xin Wen, Xiao-Jing Yang, Jun Ma, Na Liu |
| Source: |
PLoS ONE, Vol 10, Iss 3, p e0122228 (2015) |
| Publisher Information: |
Public Library of Science (PLoS), 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Based on our recent microarray analysis, we found that miR-145 was obviously downregulated in nasopharyngeal carcinoma (NPC) tissues. However, little is known about its function and mechanism involving in NPC development and progression.Quantitative RT-PCR was used to detect miR-145 expression in NPC cell lines and clinical samples. Wound healing, Transwell migration and invasion, three-dimension spheroid invasion assays, and lung metastasis model were performed to test the migratory, invasive, and metastatic ability of NPC cells. Luciferase reporter assay, quantitative RT-PCR, and Western blotting were used to verify the target of miR-145.MiR-145 was obviously decreased in NPC cell lines and clinical samples (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC4376852?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0122228 |
| Access URL: |
https://doaj.org/article/21d968ca76274acb8d82adc360abf55b |
| Accession Number: |
edsdoj.21d968ca76274acb8d82adc360abf55b |
| Database: |
Directory of Open Access Journals |
